STRUCTURAL FEATURES OF THE WALL OF MYOCARDIAL INTRAMURAL VESSELS AND THE CONTENT OF HOMOCYSTEIN IN THE BLOOD PLASMA UNDER THE LINDANE AND SODIUM DICHROMATE EXPOSURE

Abstract

Aim. Determine indicators of the vascular wall of the ventricular myocardium and the level of homocysteine in the blood when exposed to sodium dichromate and lindane under experimental conditions. Methods of the Research. The experiment was carried out on male mice; the histological method, morphometry of the obtained data, biochemichal blood analysis, and the statistical processing of the research data were used. Results. When exposed to sodium dichromate in the 1st month of the experiment, the myocardial arteries of the anterior wall of the left ventricle were thickened by 3.8 px compared with the control, in the 2nd month of the experiment this indicator was close to those of the control group. When compared between the two experimental groups, no clear changes were found. The revealed changes in the myocardial artery of the posterior wall of the left ventricle are similar to those of the anterior wall artery. The content of homocysteine under the exposure to sodium dichromate in the 1st month is higher, in the 2nd month of the experiment it is slightly reduced compared to the 1st month. The data obtained in the lindane treatment group both in the 1st and 2nd months of the experiment were close to those of the control group. Conclusion. Chronic exposure to sodium dichromate and lindane causes thickening of the walls of the intramural arteries, which was accompanied by an increase in the level of the endothelial dysfunction marker — homocysteine in the blood, while increasing further damage to the walls of the arteries in the myocardium.