Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-2-63-69
A. Ovchinnikov, I. Klimova, Yu.S. Volnaya
Currently, the possible role of intestinal microorganisms in the etiology and pathogenesis of mental illness is being actively studied all over the world. Every year the number of studies is steadily increasing, however, in the Russian-speaking environment, an awareness of this issue and the number of extensive reviews of scientific literature still remain at an insignificant level. The aim of this study is to review and systematize the scientific literature and clinical studies on the impact of the intestinal microbiome on the etiology and pathogenesis of depression, schizophrenia, autism spectrum disorders, Alzheimer's disease, bipolar disorder, and obsessive-compulsive disorder. The actual studies were conducted in sick volunteers and animal models using different approaches: comparison of the composition of the gut microbiota between affected subjects and controls; observation of behavioral changes in affected subjects after administration of pathogenic intestinal microbiota or probiotics. Definite regularities in the change in the qualitative and quantitative composition of the taxonomic units of various microorganisms were revealed.
{"title":"THE RELATIONSHIP BETWEEN MICROBIOTA AND MENTAL DISEASES","authors":"A. Ovchinnikov, I. Klimova, Yu.S. Volnaya","doi":"10.31549/2541-8289-2022-6-2-63-69","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-2-63-69","url":null,"abstract":"Currently, the possible role of intestinal microorganisms in the etiology and pathogenesis of mental illness is being actively studied all over the world. Every year the number of studies is steadily increasing, however, in the Russian-speaking environment, an awareness of this issue and the number of extensive reviews of scientific literature still remain at an insignificant level. The aim of this study is to review and systematize the scientific literature and clinical studies on the impact of the intestinal microbiome on the etiology and pathogenesis of depression, schizophrenia, autism spectrum disorders, Alzheimer's disease, bipolar disorder, and obsessive-compulsive disorder. The actual studies were conducted in sick volunteers and animal models using different approaches: comparison of the composition of the gut microbiota between affected subjects and controls; observation of behavioral changes in affected subjects after administration of pathogenic intestinal microbiota or probiotics. Definite regularities in the change in the qualitative and quantitative composition of the taxonomic units of various microorganisms were revealed.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116948611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-3-50-56
I. F. Nikulich, E.V. Salopekina
Abstract. Dry eye syndrome is widespread, with an incidence ranging from 5% to 50%, reaching up to 75% in some populations. The number of patients with this pathology is growing every year, while there is a tendency to increase in the incidence at a young age. Aim of the study. To estimate the frequency of DES among medical university students depending on various risk factors. Materials and methods. 52 students of medical university participated in extensive ophthalmic investigation, the median age was 22.8 ± 2.6 years. The OSDI (ocular surface disease index) questionnaire is used to evaluate subjective symptoms of dry eye syndrome. Risk factors for the development and progression of DES were registered: long-term wearing of personal protective equipment (PPE) for respiratory organs and the eye surface, wearing of soft contact lenses, keratorefractive surgery, and diseases of eye and blepharon in past medical history, duration of electronic devices use. Results. The OSDI questionnaire revealed the presence of DES in 56% of the subjects: mild — in 38%, moderate — in 12%, severe — in 6%; the tear film break-up time (TFBT) revealed the presence of DES in 48%. The presence of at least one DES risk factor was found in 71% of students, two factors — in 26.9%, and three or more — in 13.5%. Long-term computer use (50%), prolonged wearing of PPE for respiratory organs and the eye surface (30.7%) and wearing soft contact lenses (19.2%) were the most common. A relationship between the presence of risk factors and the prevalence of DES has been established: according to OSDI questionnaire the prevalence of DES is greater than 30% in persons with risk factors, and according to TFBT is greater than 14%. Conclusion. The revealed high incidence of DES among medical students is a result of scientific and technological progress (computerization in all areas including education), current epidemiological situation (wearing of personal protective equipment) and noticeable increase in the number of ophthalmological patients who need vision correction (with soft contact lenses or keratorefractive surgery). The presence of these risk factors reinforces already existing increasing trend in the prevalence of DES.
{"title":"PREVALENCE OF DRY EYE SYNDROME AMONG MEDICAL UNIVERSITY STUDENTS DEPENDING ON VARIOUS RISK FACTORS","authors":"I. F. Nikulich, E.V. Salopekina","doi":"10.31549/2541-8289-2022-6-3-50-56","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-3-50-56","url":null,"abstract":"Abstract. Dry eye syndrome is widespread, with an incidence ranging from 5% to 50%, reaching up to 75% in some populations. The number of patients with this pathology is growing every year, while there is a tendency to increase in the incidence at a young age. Aim of the study. To estimate the frequency of DES among medical university students depending on various risk factors. Materials and methods. 52 students of medical university participated in extensive ophthalmic investigation, the median age was 22.8 ± 2.6 years. The OSDI (ocular surface disease index) questionnaire is used to evaluate subjective symptoms of dry eye syndrome. Risk factors for the development and progression of DES were registered: long-term wearing of personal protective equipment (PPE) for respiratory organs and the eye surface, wearing of soft contact lenses, keratorefractive surgery, and diseases of eye and blepharon in past medical history, duration of electronic devices use. Results. The OSDI questionnaire revealed the presence of DES in 56% of the subjects: mild — in 38%, moderate — in 12%, severe — in 6%; the tear film break-up time (TFBT) revealed the presence of DES in 48%. The presence of at least one DES risk factor was found in 71% of students, two factors — in 26.9%, and three or more — in 13.5%. Long-term computer use (50%), prolonged wearing of PPE for respiratory organs and the eye surface (30.7%) and wearing soft contact lenses (19.2%) were the most common. A relationship between the presence of risk factors and the prevalence of DES has been established: according to OSDI questionnaire the prevalence of DES is greater than 30% in persons with risk factors, and according to TFBT is greater than 14%. Conclusion. The revealed high incidence of DES among medical students is a result of scientific and technological progress (computerization in all areas including education), current epidemiological situation (wearing of personal protective equipment) and noticeable increase in the number of ophthalmological patients who need vision correction (with soft contact lenses or keratorefractive surgery). The presence of these risk factors reinforces already existing increasing trend in the prevalence of DES.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117154614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2021-3-44-47
Аnatoly V. Kuznetsov, L. Kostina, A. Novikov, G.M. Ryngach, V. Melnikov, Е.А. Ovchinnikov, Е.А. Lazutkina, V. A. Kuznetsov
{"title":"SELECTION OF AN ADEQUATE METHOD FOR DRAINING PROSTHETIC CAVITY IN THE TREATMENT OF POSTOPERATIVE VENTRAL HERNIAS","authors":"Аnatoly V. Kuznetsov, L. Kostina, A. Novikov, G.M. Ryngach, V. Melnikov, Е.А. Ovchinnikov, Е.А. Lazutkina, V. A. Kuznetsov","doi":"10.31549/2541-8289-2021-3-44-47","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-3-44-47","url":null,"abstract":"","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116128907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2023-7-1-29-35
N. P. Kareva, E. Shvelidze, G. S. Logacheva
The aim of the study was to evaluate the effectiveness of the combined use of EHF-puncture and hirudotherapy (HT) in chronic pelvic inflammatory diseases in women and to substantiate the expediency of including a combination of these non-drug therapeutic factors in the combination treatment of pelvic inflammatory diseases (PID). Under observation there were 128 women aged 20 to 45 years (31.8 ± 0.41 years) with chronic adnexitis, chronic endometritis and both diseases at the stage of complete and incomplete remission. In 70.3% of patients, concomitant hormone-dependent diseases were recorded: fibromyoma of the uterine body, endometriosis and their combination. All patients were randomized into 2 groups: the main group (74 subjects) and the comparison group (54 subjects). The multimodality treatment of patients of the main group included EHF-therapy through the action upon biologically active points (BAP) and HT. The effectiveness of the treatment was assessed by the results of the analysis of the visual analogue scale of pain, bimanual and ultrasound examination data in dynamics. The combined use of EHF-puncture and hirudotherapy ensured the achievement of an analgesic effect in 82.9% of cases, an anti-inflammatory effect in 51.8% of cases, a resolving effect in 93.7% of cases, and contributed to the normalization of hemodynamics of the pelvic organs in 68.8% of cases. Under the influence of EHF-puncture and HT, the manifestations of endometriosis and fibromyoma of the uterine body decreased. The results of the study prove the clinical effectiveness of the combined use of EHF-puncture and hirudotherapy in the treatment of PID in women, including those with concomitant hormone-dependent gynecological diseases.
{"title":"EHF-THERAPY AND HIRUDOTHERAPY IN THE COMBINATION TREATMENT OF CHRONIC PELVIC INFLAMMATORY DISEASES IN WOMEN","authors":"N. P. Kareva, E. Shvelidze, G. S. Logacheva","doi":"10.31549/2541-8289-2023-7-1-29-35","DOIUrl":"https://doi.org/10.31549/2541-8289-2023-7-1-29-35","url":null,"abstract":"The aim of the study was to evaluate the effectiveness of the combined use of EHF-puncture and hirudotherapy (HT) in chronic pelvic inflammatory diseases in women and to substantiate the expediency of including a combination of these non-drug therapeutic factors in the combination treatment of pelvic inflammatory diseases (PID). Under observation there were 128 women aged 20 to 45 years (31.8 ± 0.41 years) with chronic adnexitis, chronic endometritis and both diseases at the stage of complete and incomplete remission. In 70.3% of patients, concomitant hormone-dependent diseases were recorded: fibromyoma of the uterine body, endometriosis and their combination. All patients were randomized into 2 groups: the main group (74 subjects) and the comparison group (54 subjects). The multimodality treatment of patients of the main group included EHF-therapy through the action upon biologically active points (BAP) and HT. The effectiveness of the treatment was assessed by the results of the analysis of the visual analogue scale of pain, bimanual and ultrasound examination data in dynamics. The combined use of EHF-puncture and hirudotherapy ensured the achievement of an analgesic effect in 82.9% of cases, an anti-inflammatory effect in 51.8% of cases, a resolving effect in 93.7% of cases, and contributed to the normalization of hemodynamics of the pelvic organs in 68.8% of cases. Under the influence of EHF-puncture and HT, the manifestations of endometriosis and fibromyoma of the uterine body decreased. The results of the study prove the clinical effectiveness of the combined use of EHF-puncture and hirudotherapy in the treatment of PID in women, including those with concomitant hormone-dependent gynecological diseases.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122963773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2023-7-2-12-18
V. Mironova, A. Sudarkina, A. Dergilev
The aim of the study is to demonstrate the possibilities of T2*-perfusion in the differential diagnosis of changes in the postoperative zone in patients operated for brain neoplasms. We retrospectively analyzed the data of magnetic resonance imaging using contrast-enhanced MR perfusion, its leading indicator being cerebral blood flow (CBF). As a result of the study, the areas of the increased (corresponding to tumor infiltration) and reduced (corresponding to granulation tissue/ischemic foci) cerebral blood flow were identified which is a determinative differential diagnostic criterion.
{"title":"POSSIBILITIES OF MAGNETIC RESONANCE PERFUSION IN POSTOPERATIVE CONTROL IN PATIENTS OPERATED FOR BRAIN NEOPLASMS","authors":"V. Mironova, A. Sudarkina, A. Dergilev","doi":"10.31549/2541-8289-2023-7-2-12-18","DOIUrl":"https://doi.org/10.31549/2541-8289-2023-7-2-12-18","url":null,"abstract":"The aim of the study is to demonstrate the possibilities of T2*-perfusion in the differential diagnosis of changes in the postoperative zone in patients operated for brain neoplasms. We retrospectively analyzed the data of magnetic resonance imaging using contrast-enhanced MR perfusion, its leading indicator being cerebral blood flow (CBF). As a result of the study, the areas of the increased (corresponding to tumor infiltration) and reduced (corresponding to granulation tissue/ischemic foci) cerebral blood flow were identified which is a determinative differential diagnostic criterion.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124554872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-1-38-44
Е.А. Epanchintseva, V. Selyatitskaya, I. V. Feofilov
Introduction. According to the Russian Society of Urology, the frequency of infertile marriages, one of the causes of which is the male factor, ranges from 8 to 17.2% in various regions of Russia. The genesis of male infertility is multifactorial and one of the possible causes of fertility disorders can currently be COVID-19. Since SARS-CoV-2 enters the body through the angiotensin-converting enzyme 2 receptor, high expression of this enzyme in testicular cells may contribute to impaired spermatogenesis. Aim of the Research. To study changes in the spermiological status of men from infertile couples over the period of 2013–2020 with an emphasis on the COVID-19 pandemic period. Materials and methods. Design — observational, retrospective, cross-sectional study. The analysis of case histories of 1006 men living in Novosibirsk from couples with infertility in marriage was carried out. The samples were divided into 4 groups: 1 (n = 696) — 2013–2017; 2 (n = 68) — 2018; 3 (n = 163) — 2019; 4 (n = 79) — 2020. We have carried out an analysis of spermograms, spermatozoa morphology according to Kruger strict criteria, MAR test. Results are presented as median, 25 and 75 percentiles. Results. In the total sample, a reduced proportion of morphologically normal forms relative to the reference was revealed (median of 2.5% with reference values > 4.0%). Progressive sperm motility decreases from group 1 to group 3 and is stable in groups 3 and 4: 40.0 (25.0–52.0); 37.5 (22.5–53.0); 30.0 (19.4–42.3) and 30.0 (21.5–41.2); p1–3. 1–4 < 0.005. The proportion of morphologically normal spermatozoa decreases from group 1 to 2, then it is stable: 4.0 (2.0–6.0); 2.5 (1.5–3.0); 2.0 (1.5–3.0); 2.0 (1.0–3.0); p1–2, 1–3, 1–4 < 0.005. For the MAR test, a gradual decrease from group 1 to 3 and an increase in group 4 were revealed: 2.0 (0.0–6.0); 0.75 (0.0–2.8); 0.5 (0.0–2.5); 1.5 (0.0–4.0), p2–3 < 0.005. Conclusion. Within the period of 2013–2020, in men from infertile couples, a gradual increase in the incidence of astheno- and teratozoospermia was revealed, while the concentration and number of spermatozoa did not change, the prevalence of the immune form of male infertility increased. Considering the decrease in spermogram indicators for 2013–2020 with minimal indicators in 2020, it can be assumed that COVID-19 is one of the factors affecting fertility, but is not the main one, which requires continued research aimed at clarifying the genesis of male infertility.
{"title":"DYNAMICS OF EJACULATE CHANGES IN MEN FROM INFERTILE COUPLES IN 2013–2020 WITH AN EMPHASIS ON THE PERIOD OF COVID-19","authors":"Е.А. Epanchintseva, V. Selyatitskaya, I. V. Feofilov","doi":"10.31549/2541-8289-2022-6-1-38-44","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-1-38-44","url":null,"abstract":"Introduction. According to the Russian Society of Urology, the frequency of infertile marriages, one of the causes of which is the male factor, ranges from 8 to 17.2% in various regions of Russia. The genesis of male infertility is multifactorial and one of the possible causes of fertility disorders can currently be COVID-19. Since SARS-CoV-2 enters the body through the angiotensin-converting enzyme 2 receptor, high expression of this enzyme in testicular cells may contribute to impaired spermatogenesis. Aim of the Research. To study changes in the spermiological status of men from infertile couples over the period of 2013–2020 with an emphasis on the COVID-19 pandemic period. Materials and methods. Design — observational, retrospective, cross-sectional study. The analysis of case histories of 1006 men living in Novosibirsk from couples with infertility in marriage was carried out. The samples were divided into 4 groups: 1 (n = 696) — 2013–2017; 2 (n = 68) — 2018; 3 (n = 163) — 2019; 4 (n = 79) — 2020. We have carried out an analysis of spermograms, spermatozoa morphology according to Kruger strict criteria, MAR test. Results are presented as median, 25 and 75 percentiles. Results. In the total sample, a reduced proportion of morphologically normal forms relative to the reference was revealed (median of 2.5% with reference values > 4.0%). Progressive sperm motility decreases from group 1 to group 3 and is stable in groups 3 and 4: 40.0 (25.0–52.0); 37.5 (22.5–53.0); 30.0 (19.4–42.3) and 30.0 (21.5–41.2); p1–3. 1–4 < 0.005. The proportion of morphologically normal spermatozoa decreases from group 1 to 2, then it is stable: 4.0 (2.0–6.0); 2.5 (1.5–3.0); 2.0 (1.5–3.0); 2.0 (1.0–3.0); p1–2, 1–3, 1–4 < 0.005. For the MAR test, a gradual decrease from group 1 to 3 and an increase in group 4 were revealed: 2.0 (0.0–6.0); 0.75 (0.0–2.8); 0.5 (0.0–2.5); 1.5 (0.0–4.0), p2–3 < 0.005. Conclusion. Within the period of 2013–2020, in men from infertile couples, a gradual increase in the incidence of astheno- and teratozoospermia was revealed, while the concentration and number of spermatozoa did not change, the prevalence of the immune form of male infertility increased. Considering the decrease in spermogram indicators for 2013–2020 with minimal indicators in 2020, it can be assumed that COVID-19 is one of the factors affecting fertility, but is not the main one, which requires continued research aimed at clarifying the genesis of male infertility.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130332885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-4-24-29
A. P. Nadeev, A. A. Abyshev, K.A. Nizovtsev
Fatal outcomes in visceral syphilis are now rare. The article presents data on the epidemiology, nosological forms of visceral syphilis and the description of the lethal outcome. In observations, late syphilis was characterized by multiple organ lesions (heart, brain, skin), but the leading clinical manifestations referred to neurosyphilis and cardiovascular syphilis. The diagnosis of visceral syphilis was established intra-vitam and at autopsy on the basis of a characteristic morphological picture (detection of gummas) and positive test results for antibodies to Treponema pallidum.
{"title":"TERTIARY POLYVISCERAL SYPHILIS: CLINICAL AND ANATOMICAL OBSERVATION OF A FATAL OUTCOME","authors":"A. P. Nadeev, A. A. Abyshev, K.A. Nizovtsev","doi":"10.31549/2541-8289-2022-6-4-24-29","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-4-24-29","url":null,"abstract":"Fatal outcomes in visceral syphilis are now rare. The article presents data on the epidemiology, nosological forms of visceral syphilis and the description of the lethal outcome. In observations, late syphilis was characterized by multiple organ lesions (heart, brain, skin), but the leading clinical manifestations referred to neurosyphilis and cardiovascular syphilis. The diagnosis of visceral syphilis was established intra-vitam and at autopsy on the basis of a characteristic morphological picture (detection of gummas) and positive test results for antibodies to Treponema pallidum.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127932265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-2-34-42
G. Vereshchagina, E.A. Domshinskaya, A. Dergilev, A. Ilyin
Systemic dysplasia is a formation pathology of the connective tissue structures. With a high prevalence of systemic connective tissue dysplasia (SCTD), the insufficient awareness of doctors about the possibilities of its early diagnosis and correction, starting from the stage of pediatric care, draws attention. Progressive asymmetries of the skeleton already from childhood lead to additional trauma of all genetically determined, but at the same time defective connective tissue structures. The aim of the work was to improve the efficiency of diagnosis and treatment of diseases of the temporomandibular joint (TMJ) in persons with SCTD. The results of a study of 507 patients of different ages are presented. Comparative radiography of the lower extremities reveals a row of pathological changes in the hip and knee joints, the difference in the length of the femurs, lower legs; the height of the iliac wings, scoliosis of the lumbar spine, allowing us to consider them as a complex of Short Leg Syndrome in the framework of SCTD. Asymmetries of the bone structures of the lower jaw are often aggravated by hypertonicity of the masticatory muscles. According to the results of radiological examination, various bone asymmetries of the maxillofacial region (MFR), of the lower extremities within 5–15 mm of relative length, centric jaw relation abnormalities, pathological changes in the masticatory muscles, dislocation of the TMJ articular disc, positional asymmetry of the external auditory canals were revealed. The information obtained allows us to construct a diagnostic algorithm. Ultrasound of the heart, abdominal organs, and kidneys in a standing position were performed to diagnose visceral signs of SCTD. The methods of diagnosis of skeletal asymmetries include: orthopantomography (OPTG) of the MFR, transoral radiography of C1-C2, comparative radiography of the lower extremities, computed tomography and conebeam computed tomography of the MFR capturing the structures of the joint and three upper cervical vertebrae, magnetic resonance imaging of the TMJ. Bone asymmetries are combined with asymmetries of muscle structures, increasing postural imbalance. Multiple anatomical incongruences are aggravated by muscular imbalance in the TMJ biomechanics, which, in the context of systemic connective tissue dysplasia, significantly complicates standard treatment tactics, and worsens the prognosis and remote catamnesis.
{"title":"POSSIBILITIES FOR DIAGNOSIS AND CURATION OF TEMPOROMANDIBULAR JOINT PATHOLOGY GIVEN THE MASTICATORY MUSCLES HYPERTONICITY IN PERSONS WITH SYSTEMIC CONNECTIVE TISSUE DYSPLASIA","authors":"G. Vereshchagina, E.A. Domshinskaya, A. Dergilev, A. Ilyin","doi":"10.31549/2541-8289-2022-6-2-34-42","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-2-34-42","url":null,"abstract":"Systemic dysplasia is a formation pathology of the connective tissue structures. With a high prevalence of systemic connective tissue dysplasia (SCTD), the insufficient awareness of doctors about the possibilities of its early diagnosis and correction, starting from the stage of pediatric care, draws attention. Progressive asymmetries of the skeleton already from childhood lead to additional trauma of all genetically determined, but at the same time defective connective tissue structures. The aim of the work was to improve the efficiency of diagnosis and treatment of diseases of the temporomandibular joint (TMJ) in persons with SCTD. The results of a study of 507 patients of different ages are presented. Comparative radiography of the lower extremities reveals a row of pathological changes in the hip and knee joints, the difference in the length of the femurs, lower legs; the height of the iliac wings, scoliosis of the lumbar spine, allowing us to consider them as a complex of Short Leg Syndrome in the framework of SCTD. Asymmetries of the bone structures of the lower jaw are often aggravated by hypertonicity of the masticatory muscles. According to the results of radiological examination, various bone asymmetries of the maxillofacial region (MFR), of the lower extremities within 5–15 mm of relative length, centric jaw relation abnormalities, pathological changes in the masticatory muscles, dislocation of the TMJ articular disc, positional asymmetry of the external auditory canals were revealed. The information obtained allows us to construct a diagnostic algorithm. Ultrasound of the heart, abdominal organs, and kidneys in a standing position were performed to diagnose visceral signs of SCTD. The methods of diagnosis of skeletal asymmetries include: orthopantomography (OPTG) of the MFR, transoral radiography of C1-C2, comparative radiography of the lower extremities, computed tomography and conebeam computed tomography of the MFR capturing the structures of the joint and three upper cervical vertebrae, magnetic resonance imaging of the TMJ. Bone asymmetries are combined with asymmetries of muscle structures, increasing postural imbalance. Multiple anatomical incongruences are aggravated by muscular imbalance in the TMJ biomechanics, which, in the context of systemic connective tissue dysplasia, significantly complicates standard treatment tactics, and worsens the prognosis and remote catamnesis.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"357 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121708900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2021-1-16-21
P. Trushin, Y. Chikinev, S. Shtofin, G. V. Slizovskiy
An experimental comparative study of regenerative processes of bone tissue in animals when filling bone cavities with titanium nickelide granules, and free bone grafting was carried out. It was shown, that when using finely granulated titanium nickelide, in comparison with bone chips, the formation of organotypic regenerate was accelerated by 3 months. The clinical study included 55 patients with dystrophic bone cysts, of which 30 patients underwent original plastic surgery of bone cavities with finely granulated titanium nickelide implant. The clinical and radiological effectiveness of these methods of treatment in the early rehabilitation period and in long-term follow-up, as well as a greater number of favorable results in comparison with traditional methods of treatment was demonstrated.
{"title":"NEW TECHNOLOGIES IN PLASTIC REPAIR OF RESIDUAL BONE CAVITIES","authors":"P. Trushin, Y. Chikinev, S. Shtofin, G. V. Slizovskiy","doi":"10.31549/2541-8289-2021-1-16-21","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-1-16-21","url":null,"abstract":"An experimental comparative study of regenerative processes of bone tissue in animals when filling bone cavities with titanium nickelide granules, and free bone grafting was carried out. It was shown, that when using finely granulated titanium nickelide, in comparison with bone chips, the formation of organotypic regenerate was accelerated by 3 months. The clinical study included 55 patients with dystrophic bone cysts, of which 30 patients underwent original plastic surgery of bone cavities with finely granulated titanium nickelide implant. The clinical and radiological effectiveness of these methods of treatment in the early rehabilitation period and in long-term follow-up, as well as a greater number of favorable results in comparison with traditional methods of treatment was demonstrated.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130072837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2021-2-24-28
A. I. Kichigin, A. Dergilev, V. Byvaltsev
The charts of the apparent diffusion coefficient (ADC) of patients with histologically confirmed tumors of the brain and spinal canal were analyzed according to the data of magnetic resonance imaging studies performed before surgical treatment. Analysis of the data revealed that the indexes on the ADC-charts largely correlate with the activity of tumor cell proliferation. The signal on the ADC-charts in malignant tumors of grade 3 and 4 is significantly lower than in tumors with low malignancy of 1 and 2 grade. Analysis of ADC-charts in patients with pathological lesions in the central nervous system can be used not only for differential diagnosis, but also embodied in the supposed pathomorphological characteristics of the lesion, thereby influencing the planning of the volume of surgical intervention and treatment options.
{"title":"DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING AS A PREDICTOR OF THE PROLIFERATIVE POTENTIAL OF CENTRAL NERVOUS SYSTEM TUMORS","authors":"A. I. Kichigin, A. Dergilev, V. Byvaltsev","doi":"10.31549/2541-8289-2021-2-24-28","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-2-24-28","url":null,"abstract":"The charts of the apparent diffusion coefficient (ADC) of patients with histologically confirmed tumors of the brain and spinal canal were analyzed according to the data of magnetic resonance imaging studies performed before surgical treatment. Analysis of the data revealed that the indexes on the ADC-charts largely correlate with the activity of tumor cell proliferation. The signal on the ADC-charts in malignant tumors of grade 3 and 4 is significantly lower than in tumors with low malignancy of 1 and 2 grade. Analysis of ADC-charts in patients with pathological lesions in the central nervous system can be used not only for differential diagnosis, but also embodied in the supposed pathomorphological characteristics of the lesion, thereby influencing the planning of the volume of surgical intervention and treatment options.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131530158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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