{"title":"Proteasomes: Molecular Machines for Protein Degradation","authors":"S. Witt, W. Baumeister","doi":"10.1002/3527600035.BPOL7014","DOIUrl":null,"url":null,"abstract":"Introduction: Controlling Intracellular Proteolysis \nHistorical Outline \nOccurrence and Subunit Composition of 20S Proteasomes \nStructural Features of the 20S Proteasome \nCatalytic Mechanism of the 20S Proteasome \nProcessing and Assembly of 20S Proteasomes \nSize Distribution of 20S Proteasome Products \nThe 19S Regulatory Complex \nSubcomplexes and Subunits of the 19S Regulator \nThe PA28 Activator \nOutlook and Perspectives \n \n \nKeywords: \n \n20S/26S proteasome; \n19S regulatory complex; \nprotein degradation; \nubiquitin; \nproteolysis; \nmacromolecular assembly; \nNtn hydrolases; \nPA28 activator","PeriodicalId":165163,"journal":{"name":"Biopolymers Online","volume":"32 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2002-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biopolymers Online","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/3527600035.BPOL7014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Controlling Intracellular Proteolysis
Historical Outline
Occurrence and Subunit Composition of 20S Proteasomes
Structural Features of the 20S Proteasome
Catalytic Mechanism of the 20S Proteasome
Processing and Assembly of 20S Proteasomes
Size Distribution of 20S Proteasome Products
The 19S Regulatory Complex
Subcomplexes and Subunits of the 19S Regulator
The PA28 Activator
Outlook and Perspectives
Keywords:
20S/26S proteasome;
19S regulatory complex;
protein degradation;
ubiquitin;
proteolysis;
macromolecular assembly;
Ntn hydrolases;
PA28 activator
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