A Study on Prevalence of Serum Resistant & Sensitive Escherichia Coli in Urinary Tract Infection

K. Prakash, J. Kumar, J. Rajamouli, Sachin Gurnule
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Abstract

Background: Escherichia coli is the commonest organism causing urinary tract infection in women and children especially in those with uncom- plicated infections. It has been traditionally described Serotypes of Escherichia coli were consistently associated with Uropathogenicity and designated as Uropathogenic Escherichia coli.It is now recognized that a subset of fecal Escherichia coli can be colonized in the peri-urethral area, enter the urinary tract and cause symptomatic disease. These are currently defined as Uropathogenic Escherichia coli. The aims & objectives are to the isolation of Escherichia coli in Urinary tract infection. 2. To determine the prevalence of Serum resistant Uropathogenic Escherichia coli. 3. To compare antimicrobial efficacy in Serum resistant and Serum sensitive Uropathogenic Escherichia coli. Subjects & Methods: An observational study was conducted on 100 patients and urine samples collected from suspected and suffering from urinary tract infection. Study period from August 2018 to July 20019 attending General medicine OP in Hospital. Escherichia coli were isolated and identified by conventional techniques Mackie & Mc Cartney. The strains were subjected to multiple drugs to study serum resistance and sensitivity. Results: From 100 urine samples 71 Uropathogenic, 18 males & 53 females. 40% Sero-resistant and 60% Sero-sensitive among them 2 to 18 years males and > 40 years females resistant, above 40 years males and 19 to 40 years females are sensitive to multiple antibiotics. Conclusion: it emphasizes Serum resistance is an important virulence factor, It may lead to pyelonephritis and septicemia. Serum resistant E. coli are multiple drug-resistant, so the present study formulating guidelines for planning effective treatment and Periodic surveillance to monitor resistance.
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尿路感染血清耐药和敏感大肠杆菌流行病学研究
背景:大肠杆菌是引起妇女和儿童尿路感染的最常见的微生物,特别是在那些无并发症的感染中。传统上,大肠杆菌的血清型与尿路致病性一致,并被指定为尿路致病性大肠杆菌。现在认识到,粪便大肠杆菌的一个亚群可以在尿道周围区域定植,进入尿路并引起症状性疾病。这些目前被定义为尿路致病性大肠杆菌。目的和目的是分离尿路感染中的大肠杆菌。2. 目的:了解血清耐药尿路致病性大肠杆菌的流行情况。3.比较血清耐药与血清敏感尿路致病性大肠杆菌的抗菌效果。对象与方法:对100例疑似尿路感染患者及尿标本进行观察性研究。研究期间为2018年8月至20019年7月在医院全科门诊就诊。采用传统的麦基和麦卡特尼技术对大肠杆菌进行分离鉴定。对该菌株进行多种药物的血清耐药性和敏感性研究。结果:100份尿样71例,男18例,女53例。其中2 ~ 18岁男性、> 40岁女性耐药、40岁以上男性、19 ~ 40岁女性对多种抗生素敏感者占40%、60%。结论:强调血清耐药是肾盂肾炎和败血症的重要毒力因素。血清耐药大肠杆菌具有多重耐药,因此本研究为制定有效治疗计划和定期监测耐药性制定指南。
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