Effects of Biofermin-R Administered in Combination with Antibiotics on the Fecal Flora

Abstract

For the purpose of investigating the effects of Biofermin-R (BF-R) on the bacterial flora, BF-R was administered in combination with antibiotics , and the fecal flora of children treated with antibiotics alone was compared with that of children treated with both BF-R and antibiotics. Three types of effects were investigated: 1) the inhibitory effect on antibiotic-induced changes of the bacterial flora in patients without diarrhea , 2) the bacterial flora-maintaining and normalizing effect in patients with gastrointestinal symptoms, and 3) the process of normalizing in the fecal bacterial flora of mice administered with antibiotics. The results indicated that the concurrent use of BF-R and an antibiotic inhibited the changes of the intestinal flora that usually occur during antibiotic therapy alone, by preventing a decrease in Bifidobacterium, and restored disturbed flora to normal.