Estimation Of CA-125 Level In First Trimester Threatened Abortion

Abstract

Objective: Serum level of CA-125 turned out to be a valuable parameter not only as a marker of ovarian carcinoma but also in other fields of obstetrics and gynecology. Earlier work suggested that highest level of CA-125 could be detected in the sera of women with threatened abortion. Design : A prospective study. Setting: Private hospital and clinics in Baghdad. Subjects: The study population comprised of 42 pregnant women who were recruited from August 2004 to September 2007 and had a vaginal bleeding in the first trimester ending in abortion. The controls were 20 pregnant women who had normal pregnancy without complications. Intervention: Blood was collected and level of CA-125 antigens (Ags) was estimated in the serum of these women by Enzyme Linked Immuno Sorbent Assay (ELISA) in Immunological laboratories in Central Public Health Laboratories and Teaching Laboratories in Medical city in Baghdad. Ultrasound confirmation of fetal heart activity was done. Main outcome measure: Pregnancy outcome and CA-125 level in the serum. RESULTS: In spite of increased level of CA-125 in aborted patients in first trimester. There was no significant difference between two groups. CONCLUSIONS: CA-125 can not be used as a predictor of outcome of early pregnancy complicated by vaginal bleeding