{"title":"Evaluation of Cell Velocity Regulation in a Microfabricated Adhesion-Based Cell Separation Device","authors":"J. Miwa, Y. Suzuki, N. Kasagi","doi":"10.1109/MMB.2006.251501","DOIUrl":null,"url":null,"abstract":"This paper reports the characterization of adhesion-based cell velocity regulation in a prototype microfabricated cell separation device for regenerative medicine. The principle of cell sorting is based on immunoreaction for accurate recognition of target stem cells. Target-cell specific antibody is immobilized on the micro channel wall to form a selectively adhesive surface, where a new class of functionalized parylene is used as the surface material for antibody immobilization. The flowing velocity of sample cells in a prototype microfabricated cell separation column is examined under the microscope. The measurement results show that the cell velocity is reduced by 40% due to the effect of antigen/antibody interaction","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2006 International Conference on Microtechnologies in Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/MMB.2006.251501","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
This paper reports the characterization of adhesion-based cell velocity regulation in a prototype microfabricated cell separation device for regenerative medicine. The principle of cell sorting is based on immunoreaction for accurate recognition of target stem cells. Target-cell specific antibody is immobilized on the micro channel wall to form a selectively adhesive surface, where a new class of functionalized parylene is used as the surface material for antibody immobilization. The flowing velocity of sample cells in a prototype microfabricated cell separation column is examined under the microscope. The measurement results show that the cell velocity is reduced by 40% due to the effect of antigen/antibody interaction
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