In vitro biocompatibility and electrochemical behavior of titanium and its alloys

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI:10.1109/MMB.2006.251478

M. Popa, D. Iordăchescu, I. Demetrescu, E. Vasilescu, P. Drob, A. Cîmpean, M. Istratescu, C. Vasilescu

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引用次数: 2

Abstract

In vitro osteoblasts/Ti-6Al-7Nb bioalloy interactions were characterized in this paper. Also, the electrochemical properties of the passive films on titanium and its Ti-6Al-7Nb bioalloy in Ringer 2 and 3 solutions were determined as an aspect of their biocompatibility. Human osteoblast proliferation and viability are very good. "Cell effort" to adhere on metallic support is visualized by some morphologic changes of the osteoblasts. Cytotoxicity effects of Ti-6Al-7Nb alloy appeared after 48 culture hours and decreased in time, demonstrating a very good biocompatibility. In Ringer 2 solution of different pH values (2.5; 5; 6.7 and 9), titanium and Ti-6Al-7Nb alloy presented self-passivation, very large passive potential range, very low passive current densities, confirming a compact, protective, stable layer. The very low corrosion rates and ion release values prove a near imperceptible toxicity. In Ringer 3 solution, open circuit potentials of titanium and its Ti-6Al-7Nb alloy tend to electropositive values, attesting a process of passivity increase by thickening

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钛及其合金的体外生物相容性及电化学行为

本文研究了体外成骨细胞与Ti-6Al-7Nb生物合金的相互作用。同时，测定了钛及其Ti-6Al-7Nb生物合金钝化膜在林格尔2和林格尔3溶液中的电化学性能，作为其生物相容性的一个方面。人成骨细胞的增殖和生存能力都很好。通过成骨细胞的一些形态学变化，可以观察到附着在金属支架上的“细胞作用力”。Ti-6Al-7Nb合金的细胞毒性作用在培养48 h后出现，并随着时间的推移而减弱，表现出很好的生物相容性。在不同pH值(2.5;5;6.7和9)，钛和Ti-6Al-7Nb合金表现出自钝化，非常大的被动电位范围，非常低的被动电流密度，确认了致密，保护，稳定的层。极低的腐蚀速率和离子释放值证明了几乎难以察觉的毒性。在Ringer - 3溶液中，钛及其Ti-6Al-7Nb合金的开路电位趋于正电，证明了增厚钝化的过程

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2006 International Conference on Microtechnologies in Medicine and Biology

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