The Inhibition of ZN Finger Transcription Factors

Abstract

Zinc fingers are among the most abundant protein motifs and play a pivotal role in cell proliferation, migration, and differentiation. Emerging studies have focused on the zinc finger transcription factors role in related diseases and discovered they are involved in activating oncogenic transcription, HIV reverse transcription, and bacterium infection. Hence, it is important to investigate and understand how zinc finger transcription factors can be selectively inhibited. The aim of this minireview is to describe how Zn Finger inhibition occurs within both a chemical and biological framework. Complexes Synthesis, inhibition mechanism, and selectivity are comprehensively reviewed. Cells utilize phosphorylation and acetylation to self-inhibit the zinc finger transcription factors by adjusting spatial structure and chemical properties. Also, we propose potential regulation sites of post transcription modification, therapeutic treatments and concerns over animal trials.