Targeting SWI/SNF metabolic vulnerabilities in cancer

Abstract

The SWI/SNF (Switch/Sucrose non-fermentable) complex is a key epigenetic regulator that is conserved across different species. While its functions as a gene expression regulator have been widely characterized, new evidences suggest that it can act as a fundamental modulator of metabolic pathways both in physiological and pathological processes. In this review, we summarized the most recent literature addressing molecular interactions involving members of the SWI/SNF complex and metabolic pathways. We focused on how genetic 1 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 3 Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy 4 Scientific Direction, Centro di Riferimento Oncologico della Basilicata IRCCS-CROB, Rionero in Vulture, Potenza, Italy 5 David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA