Calorie restriction and periodic fasting from rodent to human: lost in translation?

Abstract

. Impact statement: Dietary interventions have the potential to impact life expectancy and prevent age-related diseases like tumors and neurodegenerative disorders. However, the applicability of calorie restriction and fasting interventions from mouse models to human populations remains controversial and inconclusive. In this review, we examine the potential obstacles that may arise when attempting to apply dietary interventions from mouse models to human populations