Successful treatment of iatrogenically developed cutaneous calci-fication by tetracycline in labrador retriever

Harvima Rj, Halonen P, Pirinen E, Kolehmainen-Harvima Ks, Harvima It
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Abstract

An older of about 11-year-old Labrador retriever dog developed arthrosis especially in the right elbow with a traumatic loosened fragment that was removed in a small operation. The dog was treated first with conventional antiinflammatory drugs, e.g., paracetamol, paracetamol-codeine combination, meloxicam, and finally carprofen-tramadol combination. After these treatments failed to give an adequate response, 40-80 mg methylprednisolone was administered i.m. or s.c. at one to two-month intervals. Skin dermatitis with marked hair loss appeared with clinical appearance of impetigo-like purulent infection seen as multiple lesions. Therefore, cephalexin was administered orally for 4 weeks together with topical antimicrobial treatments with chlorhexidine. In addition, nodular itchy tumors developed. Skin biopsies taken both from areas of dermatitis and nodular lesions revealed marked skin calcification that was treated with oral tetracycline 500 mg bid for 2 months and thereafter 500 mg per day for another 2 months. The itch disappeared in 2 weeks, dermatitis in about 2-3 weeks, and nodular tumors disappeared, and the hair regrew in about 3 months after the end of tetracycline treatment.
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四环素成功治疗拉布拉多犬医源性皮肤钙化
一只大约11岁的拉布拉多猎犬患上了关节病,特别是在右肘,创伤性松动碎片在一次小手术中被移除。先用常规抗炎药物治疗,如扑热息痛、扑热息痛-可待因联合用药、美洛昔康、卡洛芬-曲马多联合用药。在这些治疗未能产生足够的反应后,每隔一至两个月给药40-80毫克甲基强的松龙。皮肤皮炎伴明显脱发,临床表现为脓疱样化脓性感染,多处病变。因此,头孢氨苄口服4周,并用氯己定进行局部抗菌治疗。此外,出现结节性瘙痒性肿瘤。皮炎和结节病变部位的皮肤活检显示明显的皮肤钙化,口服四环素500毫克,每次2个月,然后每天500毫克,再持续2个月。四环素治疗结束后2周瘙痒消失,2-3周皮炎消失,结节性肿瘤消失,3个月左右毛发再生。
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