Adriana M. Mujal, Kevin C. Barry, Edward W. Roberts, M. Binnewies, Megan K. Ruhland, Vincent Chan, M. Krummel
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引用次数: 0
Abstract
The immune response to tumors is malleable as we have learned from the various success of immunotherapies across a diversity of tumor types. What are the foundations for a solid immune response, particularly one executed by T cells? Imaging and single-cell approaches provide key insights into immune cell types that can be unleashed on tumors, identifying both their identity and the immune interactions that are to be fostered. We discuss a few of these with particular emphasis on the diversity of the myeloid system and how its component parts can contribute toward antitumor immunity. Citation Format: Adriana Mujal, Kevin Barry, Edward Roberts, Mikhail Binnewies, Megan Ruhland, Vincent Chan, Matthew Frederick Krummel. Imaging- and single cell- based insights into the antitumor immune responses [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2017 Oct 1-4; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2018;6(9 Suppl):Abstract nr IA05.
正如我们从免疫疗法在多种肿瘤类型中的成功经验中了解到的那样，对肿瘤的免疫反应是可塑的。坚实的免疫反应，特别是由T细胞执行的免疫反应的基础是什么?成像和单细胞方法提供了对可以释放到肿瘤上的免疫细胞类型的关键见解，确定了它们的身份和要培养的免疫相互作用。我们讨论其中的一些，特别强调髓系系统的多样性及其组成部分如何有助于抗肿瘤免疫。引文格式:Adriana Mujal, Kevin Barry, Edward Roberts, Mikhail Binnewies, Megan Ruhland, Vincent Chan, Matthew Frederick Krummel。基于成像和单细胞的抗肿瘤免疫反应的见解[摘要]。摘自:AACR肿瘤免疫学和免疫治疗特别会议论文集;2017年10月1-4日;波士顿,MA。费城(PA): AACR;癌症免疫学杂志，2018;6(9增刊):摘要1 - 5。
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