[The role of the serotoninergic system of the brain in cimetidine-stimulated prolactin secretion].

Abstract

Pharmacological studied were made on serotoninergic drugs (5-hydroxytryptophane, metisergid and p-chlorphenylalanin) to clarify mechanisms of cymetidine-stimulating secretion of prolactin. The experiments were carried out on white male rats at two stages: the first stage, in which dose-dependent influence of cymetidine on the release of prolactin was determined; and second stage, in which studies with indicated serotoninergic drugs after their 5-day administration were made on prolactin content after treatment with cymetidine in two doses of 20 mg/kg and 80 mg/kg of body mass. Prolactin content was determined in sera of male rats by a radioimmunological method. The results showed the influence of drugs--agonists and antagonists of serotonine on the release of prolactin after cymetid action and gave foundation to discuss them as a possible serotoninergic mechanism after cymetidine-stimulating secretion of prolactin. The results indicate the possibilities for clinical trial of serotoninergic drugs as correction of the side effect of cymetidine on prolactin secretion.