{"title":"[The cytofluorimetric characteristics of monoclonal antibodies for use in humans in respect of their activity and cross reactivity].","authors":"G Davidkova, Kh Taskov, E Dimitrova, G Gencheva","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A cytofluorimetric method for determination of the reactivity of antimyeloma MkAt 225,28S with myeloma cells and blood elements is described in the present article. The obtained results show that the antibody possesses high specific activity and does not bind with normal human lymphocytes, monocytes, granulocytes, thrombocytes and erythrocytes in the examined dilutions. The method is suitable for control of cross reactivity with blood cells of MkAt preparations for usage in subjects.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"29 2","pages":"46-52"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eksperimentalna meditsina i morfologiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A cytofluorimetric method for determination of the reactivity of antimyeloma MkAt 225,28S with myeloma cells and blood elements is described in the present article. The obtained results show that the antibody possesses high specific activity and does not bind with normal human lymphocytes, monocytes, granulocytes, thrombocytes and erythrocytes in the examined dilutions. The method is suitable for control of cross reactivity with blood cells of MkAt preparations for usage in subjects.
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