Phospholipid-containing films for improved drug release

Jiahao Huang, S. Wettig
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Abstract

Phospholipids from natural sources can delay liquid-liquid phase separation and improve supersaturation for active pharmaceutical ingredients with poor water-solubility in aqueous media. Researchers have developed oral films containing phospholipids to enhance the dissolution efficiency of hydrophobic pharmaceutical ingredients. Phospholipid-based oral films provide an alternative approach for compounding pharmacies to formulate drugs with poor water solubility.
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改善药物释放的含磷脂薄膜
天然来源的磷脂可以延缓液-液相分离,改善水溶性差的活性药物成分在水介质中的过饱和。研究人员开发了含磷脂的口服薄膜,以提高疏水性药物成分的溶解效率。基于磷脂的口服薄膜为配制水溶性差的药物提供了一种替代方法。
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