The Potential Protective Roles of S.cousts (Saussurea costus) Root in Thyroiditis Induced by Amiodarone-Hydrochloride in Experimental Rats

Abstract

Aim: S.costus root is one of the most medicinal plants that are high in antioxidants. The aim of this work was to investigate the roles of an aqueous extract of S.costus root a portative effect for thyroiditis in rats.Material and Methods: Thirty six rats were randomly divided into six groups (n = 6). The group1 (G1) received only distill water for ten days; group 2 was treated alone with amiodarone hydrochloride 40 mg/kg b.wt. per day for ten days. Groups 3 & 4 were treated orally with an aqueous extract of S. costus alone in two doses (L1 & L2) (50 & 100 mg/kg body weight/day). Groups 5 and 6 were given an aqueous extract of S. costus at two doses (L1 & L2), respectively plus administrated the amiodarone hydrochloride 40 mg/kg body weight and continued for ten days. Results: The results showed the levels of SOD and total anti-oxidant were decreased significantly (p ≤ 0.01) in (G2) rats with thyroiditis compared to all treated groups and the control group. Animals in groups (3-6) ingested extracts S. costus improved and decreased significantly (p ≤ 0.01) in CRP, TNF-a, T3, and T4 hormone levels compared to rats had amiodarone alone. Conclusion: We can conclude that using the S.costus extract considers the potential effect against amiodarone and the side effects. Also, the aqueous extract of S.costus may offer benefits as a treatment to decrease thyroiditis and hyperthyroidism.