Evidencias clínicas del uso de moduladores de la microbiota intestinal para el tratamiento de trastornos mentales: una revisión bibliográfica sistemática

Abstract

There is an association between intestinal dysbiosis, the gut–brain axis and mental health. PubMed, Embase and Web of Science were searched for analysing clinical trials in which microbiota modulators are used in mental health disorders for this systematic review. An evaluation of each study was made using CONSORT and only eight articles were suitable for this analysis: five were in depressive patients, and only one corresponded to either schizophrenia, attention-deficit/hyperactivity disorder or Alzheimer's disease. It is possible to conclude that microbiota modulators might be effective coadjuvants in traditional antidepressant or antipsychotic drugs treatment. However, the heterogeneity of interventions, small sample size, lack of intestinal microbiota assessment and symptoms auto report should be addressed before a conclusion can be made. PROSPERO registration number: CRD42020202938.