G Fyllingen, T A Langvik, P Hasselgård, P O Roksvaag
{"title":"Racemization and oxidation in adrenaline injections.","authors":"G Fyllingen, T A Langvik, P Hasselgård, P O Roksvaag","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Adrenaline injection fluids aged between 3 and 33 years were analyzed with respect to oxidation and racemization. The oxidation was determined by ion-pair reversed phase HPLC, and the degree of racemization was determined by derivatization of the adrenaline isomers to diastereomeric forms and subsequently separated by reversed phase HPLC. 10% adrenaline was oxidized after about 11 years, while 10% L-adrenaline was converted to D-adrenaline after only 4 years. After about 4 years, the injections contained less than 90% active adrenaline.</p>","PeriodicalId":7082,"journal":{"name":"Acta pharmaceutica Nordica","volume":"2 5","pages":"355-62"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta pharmaceutica Nordica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Adrenaline injection fluids aged between 3 and 33 years were analyzed with respect to oxidation and racemization. The oxidation was determined by ion-pair reversed phase HPLC, and the degree of racemization was determined by derivatization of the adrenaline isomers to diastereomeric forms and subsequently separated by reversed phase HPLC. 10% adrenaline was oxidized after about 11 years, while 10% L-adrenaline was converted to D-adrenaline after only 4 years. After about 4 years, the injections contained less than 90% active adrenaline.
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