ТЯЖЕЛАЯ КОСТНАЯ ФОРМА ГИПЕРПАРАТИРЕОЗА У БОЛЬНОЙ С АДЕНОМОЙ ПАРАЩИТОВИДНОЙ ЖЕЛЕЗЫ

К. М. Петросян, Наталья Северская, Д. Н. Дербугов, А. А. Курильчик, Н. В. Желонкина, Андрей Викторович Дементьев, Е. И. Куприянова, Г. А. Давыдов, Андрей Дмитриевич Каприн, В. Н. Галкин, Сергей Анатольевич Иванов
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Abstract

Hyperparathyroidism is one of the most common endocrinopathies. This disease leads to a violation of phosphorus-calcium metabolism and the washing out of calcium from bone tissue. Breach of the skeleton’s structure in hyperparathyroidism is often mistaken for metastatic bone damage, which leads to incorrect treatment tactics. In this work we present the clinical observation of a patient with an adenoma of the parathyroid gland and a severe bone form of hyperparathyroidism. Multiple lesions of bones with destruction of the cortical layer and the presence of the softtissue component were initially regarded as metastases in the bone. However, the morphological pattern of bone foci, as well as an elevated level of calcium and parathyroid hormone, made it possible to diagnose the bony form of hyperparathyroidism. The search for the cause of hyperparathyroidism revealed a tumor in the projection of the right lower parathyroid gland. Surgical removal of parathyroid adenoma led to the normalization of the level of calcium and parathyroid hormone. The article presents data of laboratory-instrumental methods of research and the results of surgical treatment of a patient.
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甲状腺腺样变性患者的严重骨病
甲状旁腺功能亢进是最常见的内分泌疾病之一。这种疾病会破坏磷钙代谢,导致骨组织中钙的流失。甲状旁腺功能亢进的骨骼结构破坏常被误认为是转移性骨损伤,从而导致错误的治疗策略。在这项工作中,我们提出的临床观察患者的甲状旁腺腺瘤和严重的骨形式甲状旁腺功能亢进。骨骼多发病变,伴有皮质层破坏和软组织成分的存在,最初被认为是骨转移。然而,骨病灶的形态模式,以及钙和甲状旁腺激素水平的升高,使得诊断甲状旁腺功能亢进的骨形式成为可能。对甲状旁腺功能亢进的病因的研究显示在右下甲状旁腺的投影处有一个肿瘤。手术切除甲状旁腺瘤导致钙和甲状旁腺激素水平的正常化。本文介绍了实验室仪器方法的研究数据和手术治疗患者的结果。
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