[Cerebral aminopeptidase activity: effect of the administration of imipramine].

Archivos de neurobiologia Pub Date : 1990-11-01
J M de Gandarias, J Irazusta, E Echecarría, J Múgica, L Casis
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引用次数: 0

Abstract

Imipramine is widely accepted as an effective antidepressant treatment. In this paper, changes in Lys- and Leu-aminopeptidase activities in several rat brain regions after imipramine treatment are described. Decreases of Lys-aminopeptidase activity in the olphactory bulbus, cerebellum, hypothalamus and pituitary gland were observed. In the same way, there were a decreases in Leu-aminopeptidase activity in the parietal and occipital cortices, cerebellum thalamus, hypothalamus and pituitary gland. It is suggested that these enzyme activities play a part in the imipramine action mechanism, possibly by regulating the activity of several neuroactive peptides.

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脑氨基肽酶活性:丙咪嗪的作用。
丙咪嗪被广泛认为是一种有效的抗抑郁药物。本文描述了丙咪嗪治疗后大鼠脑内几个区域的赖氨酸和亮氨酸肽酶活性的变化。观察到小鼠嗅球、小脑、下丘脑和脑垂体的赖氨酸氨基肽酶活性降低。同样,顶叶和枕叶皮层、小脑丘脑、下丘脑和脑垂体的亮氨酸肽酶活性降低。这表明这些酶的活性可能通过调节几种神经活性肽的活性而参与丙咪嗪的作用机制。
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