Analysis of cardiovascular risk factors in normolipidemic acute myocardial infarct patients on admission based on aging - A case controlled study from South Asia

Arun Kumar, S. Nagtilak, R. Sivakanesan
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引用次数: 1

Abstract

The goal of the present study was to address the various risk factors associated in normolipidemic acute myocardial infarction (AMI) patients admitted to the intensive coronary care unit (ICCU). The study compared serum lipid profiles, lipid peroxidation markers, antioxidants and inflammatory markers in acute myocardial infarction (AMI) patients and age/sex-matched controls. The risk variables were analysed age wise with patients 60 years of age.A lipid profile, lipid peroxidation, enzyme antioxidants, endogenous antioxidants, ischemia modified-albumin (IscMA), ceruloplasmin, C-reactive protein (CRP), fibrinogen, lipoprotein (a) and paraoxonase-1 activities were analyzed in 165 acute myocardial infarction (AMI) patients of which 45 patients were 60 years age of acute myocardial infarction patients. Higher levels of C-reactive protein (p=0.003) were observed among the >60 years age patients compared to <60 years. Other biochemical findings were not statistically significant.During the process of aging the risk factors vary as lowering of antioxidants is due to decreased free radical scavenging properties.
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基于年龄的正常血脂急性心肌梗死患者入院时心血管危险因素分析——南亚病例对照研究
本研究的目的是解决在冠状动脉重症监护病房(ICCU)入院的正常血脂急性心肌梗死(AMI)患者的各种相关危险因素。该研究比较了急性心肌梗死(AMI)患者和年龄/性别匹配的对照组的血清脂质谱、脂质过氧化标志物、抗氧化剂和炎症标志物。对60岁患者按年龄进行风险变量分析。分析165例急性心肌梗死(AMI)患者的脂质谱、脂质过氧化、酶抗氧化剂、内源性抗氧化剂、缺血修饰白蛋白(IscMA)、铜蓝蛋白、c反应蛋白(CRP)、纤维蛋白原、脂蛋白(A)和对氧磷酶-1活性,其中45例为60岁急性心肌梗死患者。与<60岁的患者相比,>60岁的患者c反应蛋白水平较高(p=0.003)。其他生化结果无统计学意义。在衰老过程中,风险因素各不相同,因为抗氧化剂的降低是由于自由基清除能力的下降。
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