A Andreani, M Rambaldi, A Locatelli, F Andreani, P Aresca, R Bossa, I Galatulas
{"title":"Potential antitumor agents XVII (1). Cytotoxic agents from indole derivatives and their intermediates.","authors":"A Andreani, M Rambaldi, A Locatelli, F Andreani, P Aresca, R Bossa, I Galatulas","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>New indole derivatives and their intermediates were tested as cytotoxic agents on a culture of P388 leukemia cells. The aldehyde 2a was more active than the thiosemicarbazones 3a, b and the nitrosourea 14. The chloroacetyl derivatives 10, 11 were the most potent cytotoxic agents.</p>","PeriodicalId":7082,"journal":{"name":"Acta pharmaceutica Nordica","volume":"2 6","pages":"407-14"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta pharmaceutica Nordica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
New indole derivatives and their intermediates were tested as cytotoxic agents on a culture of P388 leukemia cells. The aldehyde 2a was more active than the thiosemicarbazones 3a, b and the nitrosourea 14. The chloroacetyl derivatives 10, 11 were the most potent cytotoxic agents.
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