[Effect of neurosurgical interventions on serum levels of the essential trace elements zinc and copper--a perioperative study].

J Honegger, M Buchfelder, H Rupprecht, W Schwarz
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Abstract

The serum-concentrations of the trace-elements zinc and copper were assessed before and after neurosurgical interventions in 60 patients. On the day of surgery the mean values of zinc and copper showed a significant decrease, but had reached their preoperative level one week later. While a influence of dexamethasone on the serum zinc levels could not be deducted, the serum copper concentrations seem to be influenced by dexamethasone. These changes seem to be connected with the activation of the hypothalamus-pituitary-adrenal axis during surgical stress.

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[神经外科干预对血清必需微量元素锌和铜水平的影响——围手术期研究]。
测定60例患者神经外科干预前后血清微量元素锌、铜浓度。在手术当天,锌和铜的平均值明显下降,但一周后恢复到术前水平。虽然不能排除地塞米松对血清锌水平的影响,但血清铜浓度似乎受到地塞米松的影响。这些变化似乎与手术应激时下丘脑-垂体-肾上腺轴的激活有关。
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