Morphological changes in the tissues of the experimental model of hemangioma with concurrent medication of β-blockers and interstitial introduction of the Kenalog preparation.

Abstract

Relevance. Hemangiomas are the most common variety among tumors of the skin and soft tissues in children. The number of patients with this pathology is currently increasing. There are many methods to therapy hemangiomas in children. Currently, such drugs as Propranolol and Kenalog are widely used in the treatment of this pathology. Aim. Study the effect of β - blockers and the preparation of Kenalog on the tissues of the experimental model of hemangioma with simultaneous introduction. Materials and methods. For the experimental study, 20 live chickens were used. The histological structure of the vascular or capillary zone of the crest of the chicken resembles the human angioma. All chickens were divided into 4 groups of 5 individuals. Observing the general condition of chickens, macroscopic and histological examination of the crest of the hens were carried out. Results and conclusions. By the 15th day, all the chickens from the experimental group had died presumably because of massive vascular thrombosis. According to the result given above, simultaneous ingestion of β-blockers and interstitial administration of the Kenalog product are not recommended because of the possibility of thrombus formation and a high probability of death.