A bioimpedance-based microflow cytometer with compact electronic instrumentation for counting of microparticles

Abstract

Cell counting in microfluidic platform finds many interesting applications in healthcare and medical technology. In microflow cytometers, cells are counted based on either optical or electrical properties. In this paper, a bioimpedance based microflow cytometer has been fabricated to detect and count the microparticles flowing through a microchannel. The numerical simulation suggests that the proposed device is capable to detect microparticles having different sizes and properties. Initially, the signal produced from cytometer are collected by data accusation system demonstrating generation of voltage pulse corresponding to each particle. Additionally, an instrumentation system has been developed to detect and count those pulses in real-time and display on a screen.