Monochloroacetic acid exposure: a case report.

G D Kusch, L P McCarty, J M Lanham
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Abstract

Monochloroacetic acid exposure causes significant burns but can also be lethal following exposures of less than ten percent of body surface area. There have been two known survivors of significant monochloroacetic acid exposure. This is a case report of one of those survivors. The mechanism of toxicity is unknown, and attempts to relate monochloroacetic acid toxicity is to that of monofluoroacetic acid have yielded inconsistent results. The best mode of therapy is unclear, and no antidote has been proven effective, although ethanol and glycerol monoacetate have been suggested. The details of this case may be helpful to those faced with similar situations and to those investigating the toxicology of monochloroacetic acid.

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一氯乙酸暴露1例报告。
暴露在一氯乙酸中会造成严重的烧伤,但暴露在体表面积不到10%的地方也可能致命。已知有两名严重接触一氯乙酸的幸存者。这是其中一名幸存者的病例报告。毒性机制尚不清楚,试图将一氯乙酸的毒性与一氟乙酸的毒性联系起来的结果不一致。最佳的治疗方式尚不清楚,尽管有人建议使用乙醇和单醋酸甘油,但没有解毒剂被证明有效。这个案例的细节可能会对那些面临类似情况的人以及那些研究一氯乙酸毒理学的人有所帮助。
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