{"title":"In silico characterization of three hypothetical proteins in the Monkeypox virus","authors":"Mundaganur Dastigir, Mundaganur Yasmeen, Ashokan Kannarath","doi":"10.56781/ijsrst.2023.3.1.0034","DOIUrl":null,"url":null,"abstract":"Monkeypox virus infection and death toll are alarmingly increasing the world over. An effective treatment and control protocol is essential to fight this viral infection. In this, in silico research article, we analyzed three hypothetical protein sequences from the Monkeypox virus. We studied various parameters of these proteins including amino acid composition, instability index, isoelectric point, extinction coefficient, aliphatic index, GRAVY, etc. We also performed MSA to get a clear idea of the mutation and its type and the virus's role over time. We find out various domains and their function that permit the virus during its infection processes. The amphipathicity is validated well. This study will help scientists to develop effective drugs against this virus.","PeriodicalId":123905,"journal":{"name":"International Journal of Scholarly Research in Science and Technology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Scholarly Research in Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56781/ijsrst.2023.3.1.0034","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Monkeypox virus infection and death toll are alarmingly increasing the world over. An effective treatment and control protocol is essential to fight this viral infection. In this, in silico research article, we analyzed three hypothetical protein sequences from the Monkeypox virus. We studied various parameters of these proteins including amino acid composition, instability index, isoelectric point, extinction coefficient, aliphatic index, GRAVY, etc. We also performed MSA to get a clear idea of the mutation and its type and the virus's role over time. We find out various domains and their function that permit the virus during its infection processes. The amphipathicity is validated well. This study will help scientists to develop effective drugs against this virus.
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