Chemical/magnetic dual-responsive nanorobots with flower-like structure for drug delivery

Junfeng Wu, N. Jiao, Xingyue Hu, Lianqing Liu
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Abstract

In this paper, a facile method was used to synthesize flower-like silica (SiO2) nanoparticles. Given the advantages of porous structure for molecule decoration and drug carrying, chemical/magnetic dual-responsive nanorobots were fabricated based on these flower-like nanoparticles. Urease served as a chemical engine using urea as fuel, which provided chemical driving force for nanorobots by its biocatalytic degradation ability. Fe304 nanoparticles as a magnetic engine were responsible for the control over advance direction of nanorobots. Furthermore, dual-responsive nanorobots showed a good synergistic motion behavior without negative effect. Compared with traditional imporous nanoparticles, the flower-like structure displayed a great improvement in drug-loading properties owing to the large surface area. Furthermore, dual-responsive nanorobots lead to a higher mortality of cancer cells through an enhanced endocytosis caused by autonomous motion. Thus, the reported nanorobots are promising candidates for targeting drug delivery.
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具有花状结构的化学/磁性双响应纳米机器人,用于药物输送
本文采用一种简单的方法合成了花状二氧化硅纳米颗粒。考虑到多孔结构在分子修饰和药物携带方面的优势,基于这些花状纳米颗粒制备了化学/磁性双响应纳米机器人。脲酶作为化学发动机,以尿素为燃料,利用其生物催化降解能力为纳米机器人提供化学动力。Fe304纳米粒子作为磁引擎,控制着纳米机器人的前进方向。此外,双响应纳米机器人表现出良好的协同运动行为,没有负面影响。与传统的重要纳米颗粒相比,花状结构由于表面积大,在载药性能上有很大的提高。此外,双反应纳米机器人通过自主运动引起的内吞作用增强,导致癌细胞的死亡率更高。因此,报道的纳米机器人是靶向药物输送的有希望的候选者。
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