{"title":"Chemical/magnetic dual-responsive nanorobots with flower-like structure for drug delivery","authors":"Junfeng Wu, N. Jiao, Xingyue Hu, Lianqing Liu","doi":"10.1109/ROBIO55434.2022.10011940","DOIUrl":null,"url":null,"abstract":"In this paper, a facile method was used to synthesize flower-like silica (SiO2) nanoparticles. Given the advantages of porous structure for molecule decoration and drug carrying, chemical/magnetic dual-responsive nanorobots were fabricated based on these flower-like nanoparticles. Urease served as a chemical engine using urea as fuel, which provided chemical driving force for nanorobots by its biocatalytic degradation ability. Fe304 nanoparticles as a magnetic engine were responsible for the control over advance direction of nanorobots. Furthermore, dual-responsive nanorobots showed a good synergistic motion behavior without negative effect. Compared with traditional imporous nanoparticles, the flower-like structure displayed a great improvement in drug-loading properties owing to the large surface area. Furthermore, dual-responsive nanorobots lead to a higher mortality of cancer cells through an enhanced endocytosis caused by autonomous motion. Thus, the reported nanorobots are promising candidates for targeting drug delivery.","PeriodicalId":151112,"journal":{"name":"2022 IEEE International Conference on Robotics and Biomimetics (ROBIO)","volume":"44 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2022 IEEE International Conference on Robotics and Biomimetics (ROBIO)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ROBIO55434.2022.10011940","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In this paper, a facile method was used to synthesize flower-like silica (SiO2) nanoparticles. Given the advantages of porous structure for molecule decoration and drug carrying, chemical/magnetic dual-responsive nanorobots were fabricated based on these flower-like nanoparticles. Urease served as a chemical engine using urea as fuel, which provided chemical driving force for nanorobots by its biocatalytic degradation ability. Fe304 nanoparticles as a magnetic engine were responsible for the control over advance direction of nanorobots. Furthermore, dual-responsive nanorobots showed a good synergistic motion behavior without negative effect. Compared with traditional imporous nanoparticles, the flower-like structure displayed a great improvement in drug-loading properties owing to the large surface area. Furthermore, dual-responsive nanorobots lead to a higher mortality of cancer cells through an enhanced endocytosis caused by autonomous motion. Thus, the reported nanorobots are promising candidates for targeting drug delivery.