The additivity rule in the evaluation of health effects of combined exposure to solvents--does it hold?

J A Sokal, Z Korsak
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Abstract

On the basis of results obtained in experiments on animals exposed to mixtures of solvents the adequacy of additivity rule which is used in the evaluation of health effects of combined exposure to solvents is discussed. In the case of simultaneous exposure to mixture to toluen and xylene the modification of the additivity formula is proposed.

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综合溶剂暴露对健康影响评估中的可加性规则——是否成立?
根据动物接触混合溶剂的实验结果,讨论了用于评价混合溶剂对健康影响的可加性规则的充分性。在同时暴露于甲苯和二甲苯混合物的情况下,提出了可加性公式的修改。
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