Evaluation Biosynthesized Silver Nanoparticles By Phomatropica Against Some Multidrug Resistance Bacterial Isolates

Abstract

Researchers describe the extracellular manufacture of silver nanoparticles (AgNPs) from Phomatropica and its effectiveness against certain multidrug-resistant pathogenic bacteria that were obtained from the Central Laboratory of Quran Hospital. These bacteria were pathogenic. The AgNPs were synthesized and characterized by scan electrons microscopy, Fourier transform infrared spectroscopy, UV-visiblespectrophotometer that established the mostly spherical nanoparticles synthesis with size range between 55-99 nm. The potential antimicrobial activity was reported vs (Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, and Escherichia coli)by well diffusion method.AgNPs showed different inhibitory areas at different concentrations, the 50μg/mlconcentration of AgNPsappeared inhibition zones varied from(0-21 mm), while at 100 μg/mlofAgNPs varied between (13-25mm) vs the tested pathogenic bacterial strains in this investigation. Nevertheless, the synergetic impact of AgNPs with antibiotics have beendetected in the increasing the inhibitory impact vs the pathogenic bacteria. In conclusion, Extracellular biosynthesis appears to be a scalable and sustainable process. Because of their biogenic nature, these Ag-NPs might be a better medication candidate and have the potential to completely eliminate the issue of chemical agents.Antibiotic-resistant bacteria are proliferating at an alarming rate. To address this issue, the development of bactericidal agents is critical. AgNPs may provide a solution for drug-resistant bacteria.