[Effect of chemotherapy for neoplasms on the central nervous system in children].

Abstract

Lesions to the central nervous system were studied in twenty children, aged 1-12 years decreased because of neoplastic disease of internal organs and treated with cytostatics. The young age of the patients allowed to attribute the observed changes to this disease. Several damaging factors occurring during its course were analysed. Lesions were found in cerebral and cerebellar cortex; walls of blood vessels were also damaged. We may conclude that chemotherapy prolonging the survival of children allowed the development of encephalopathy and modified its picture.