Antibiogram of Uropathogenic Bacterial Isolates from Urine Samples

M. A. Rana, Asmara Imtiaz, K. Ahmad, Iqra Shafiq
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Abstract

ABSTRACT:Most of the bacteria of Enterobacteriaceae family are pathogenic and cause urinary tract infections, Pneumonia and diarrheal diseases. It was noticed that antimicrobials resistance of bacteria is increasing day by day that brought expanded healthcare costs due to morbidity and mortality from treatment failures. In the present study three of gram negative bacteria Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis of Enterobacteriaceae family were considered. Antibiotic susceptibility of these bacteria was checked against clinical samples by Kirby Bauer test commonly known as disc diffusion method. Eleven commercially available antibiotics i.e. Fosmomycin (FOS), Imipenem (IMP), Tazobactum (TZP), Meropenem (MEM), Amikacin (AK), Tobramycin (TOB), Nnitrofurantoin (F), Doxycycline (DO), Norfloxacin (NOR), Gentamycin (CN), and Nalidixic Acid (NA) were used to check efficacy against selected microbes.Comparison of results produced by these bacteria showed variability in resistance pattern as FOS>IPM>MEM>AK>F>F>TZP>CN>TOB>DO>NOR>NA. Fosmomycin, Imipenem, Amikacin and Meropenem were found as most effective one among all selected antibiotics
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尿路致病菌分离物的抗生素谱分析
摘要:肠杆菌科细菌大多具有致病性,可引起尿路感染、肺炎和腹泻等疾病。人们注意到,细菌对抗菌素的耐药性日益增加,由于治疗失败造成的发病率和死亡率,导致医疗费用增加。本研究考虑了肠杆菌科革兰氏阴性菌大肠杆菌、肺炎克雷伯菌和奇异变形杆菌三种。采用Kirby Bauer试验(俗称圆盘扩散法)对临床样品进行抗生素敏感性检测。11种市售抗生素,即Fosmomycin (FOS)、亚胺培南(IMP)、他唑巴坦(TZP)、美罗培南(MEM)、阿米卡星(AK)、妥布霉素(TOB)、硝基呋喃妥英(F)、强力霉素(DO)、诺氟沙星(NOR)、庆大霉素(CN)和萘利地酸(NA),用于检测对选定微生物的疗效。结果表明,这些细菌的耐药模式为FOS>IPM>MEM>AK>F>F>TZP>CN>TOB>DO>NOR>NA。在所选抗生素中,磷霉素、亚胺培南、阿米卡星和美罗培南效果最好
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