Non-invasive evaluation of blood flow through a healthy and stenosed coronary artery

Mohammed G. Al-Azawy, Zahraa Ahmed Hamza, Alaa Ahmed Alkinani
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Abstract

The current numerical analysis was utilised to compare the hemodynamic effects caused by flow disruptions in coronary arteries with and without stenosis in order to evaluate the hemodynamic importance of patient-specific coronary stenosis using Computational Fluid Dynamics (CFD) to provide information to the public, particularly surgeons, and assist them in reducing the risk of stenosis. Assuming the flow is turbulent and non-Newtonian viscosity, the Carreau model is incorporated by utilizing STAR-CCM+ 2021.2.1. The test model is a patient-specific coronary stenosis with area stenosis (60%). The velocity, shear stress, and strain rate were evaluated and revealed that the stenosed artery experiences more hemodynamic impacts as the flow rate increases compared to the normal artery. The turbulent kinetic energy and turbulent viscosity ratio findings showed that the TKE and TVR are almost the same downstream of the stenoses, with the TKE and TVR being somewhat higher with the stenosed artery model than the unstenosed artery model, and it increases as the flow increases. Moreover, to determine the stenosis severity, the coefficient of pressure drop (CDP) and lesion flow coefficient (LFC) were used and showed that the CDP value be higher in stenosed artery (107pa) compared to a normal artery (5.2pa) but it was less when the flow increased (84.4pa), (2.5pa) respectively. whereas the LFC value in the stenoses artery is higher (0.61) and rises as flow increases (0.69). 
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健康和狭窄冠状动脉血流的无创评估
目前的数值分析是用来比较有和没有狭窄的冠状动脉血流中断引起的血流动力学影响,以便利用计算流体动力学(CFD)来评估患者特异性冠状动脉狭窄的血流动力学重要性,为公众,特别是外科医生提供信息,并帮助他们降低狭窄的风险。假设流体为紊流和非牛顿黏度,采用STAR-CCM+ 2021.2.1纳入Carreau模型。试验模型为患者特异性冠状动脉狭窄伴区域性狭窄(60%)。对流速、剪应力和应变率进行了评估,结果显示,与正常动脉相比,随着流速的增加,狭窄动脉的血流动力学影响更大。湍流动能和湍流粘度比结果表明,狭窄动脉下游的TKE和TVR几乎相同,狭窄动脉模型的TKE和TVR略高于非狭窄动脉模型,并且随着流量的增加而增加。此外,通过压降系数(CDP)和病变血流系数(LFC)来判断狭窄程度,结果显示,狭窄动脉的CDP值(107pa)高于正常动脉(5.2pa),而血流增加时CDP值(84.4pa)低于正常动脉(2.5pa)。而狭窄动脉的LFC值较高(0.61),且随血流增加而升高(0.69)。
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