[Electrophoretic studies of the composition of peripheral mononuclear cells during operations with extracorporeal circulation].

Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR Pub Date : 1990-01-01

J Rychly, D Oldag, A D Krüger

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Abstract

The increased incidence of infections after operations can be connected with changes of the immunocompetent cells. Mononuclear blood-cells were investigated by means of the cell electrophoresis during and after operations under the extracorporeal circulation, because electrophoretically different cells correlate with several immunological phenotypes. A heavy decrease of the electrophoretic quick mobility cell population was found out on the first postoperative day above all. This change allows itself the interpretation by decreasing the T-lymphocytes connected to a relative increase of monocytes, B-cells, and immature T-cells. Besides a lower quotient of the quick and low mobility T-cells refers to a lower immunoregulatory quotient CD4/CD8 after operation. Changes of the cell composition becomes evident also in dependence on the bypass length and the blood supply.

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体外循环手术中外周单个核细胞组成的电泳研究。

术后感染发生率的增加可能与免疫活性细胞的改变有关。由于不同的细胞在电泳上与多种免疫表型相关，我们在体外循环下对单核血细胞在手术期间和手术后进行了细胞电泳研究。电泳快速迁移细胞数量在术后第一天明显减少。这种变化可以通过减少与单核细胞、b细胞和未成熟t细胞相对增加相关的t淋巴细胞来解释。此外，快速低流动性t细胞商数较低是指术后CD4/CD8免疫调节商数较低。细胞组成的变化也随着旁路长度和血供的变化而变得明显。

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Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR

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