[The effect of proximal selective vagotomy on experimental gastric mucosal lesions in the rat].

J Daniś, V Nosálová, J Cerný
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Abstract

The influence of the proximal selective vagotomy (PSV) on the origin and the extent of experimental gastric ulcer were investigated in rats. The lesions of the gastric mucosa were caused in three groups: by stress through swimming-test, by application of phenylbutazone, and by ischemia (ligature of the left gastric and the right gastroepiploic vessels). The PSV practised a protective influence on the pharmacodynamic etiology, however, not on the stress ulcer. The areas of the ischemic gastric ulcers were larger on an average of 40% after PSV than in the control animals. The difference was not statistically significant. In case the PSV caused besides hyposecretion and hypo-acidity even passive hyperemia caused in the denervated part of the stomach then these did not produce any sufficient defence against the origin of stress ulcers and ischemic lesions.

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[近端选择性迷走神经切断术对大鼠实验性胃粘膜病变的影响]。
探讨了近端选择性迷走神经切断术(PSV)对大鼠实验性胃溃疡发生及范围的影响。胃粘膜病变分为三组:游泳应激、苯丁酮应用、缺血(结扎左胃和右胃网膜血管)。PSV对药效学病因学有保护作用,但对应激性溃疡没有作用。PSV后的缺血性胃溃疡面积比对照组平均大40%。差异无统计学意义。如果PSV除了引起分泌减少和低酸性,甚至在胃的无神经部分引起被动充血,那么这些都不能产生任何足够的防御,以防止应激性溃疡和缺血性病变的起源。
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