Can Serum Uric Acid Predict Prediabetes in Adult Males? A Case Control Study

Abstract

It is well known that serum uric acid (SUA) involved in the metabolic dysregulations which leads to the development of type 2 diabetes mellitus (T2DM) but this relation is not fully explored with prediabetes (PreDM) which is a metabolic state characterized by higher than normal glucose level but not enough to be considered as diabetes [1,2]. About two-thirds of those with preDM will progress to T2DM [3]. Those with preDM are almost identical (regarding risk factors) to those with T2DM (advanced age, obesity and diminished physical activity...etc.) and also are predisposed to develop both micro and macrovascular complications of overt T2DM [4]. Accumulation of SUA in excess play key role in the pathogenesis of metabolic syndrome (overweight, elevated blood pressure, dyslipidemia and abnormal glucose metabolism) [5]. The Preventive Cardiology Information System (PreCIS) database assured that for each one mg/dl rise in the SUA level, there was increase in the risk of death by 39% and even after adjusting for other cardiovascular risk factors, the SUA level continued to predict the risk of death [6].