THE ASSESSMENT OF TAMARIX APHYLLA AND CALOTROPIS PROCERA COMPARATIVE AND COMBINE ANTIOXIDANT POTENTIAL

Shahid Khan, Fahim-ullah Khan, Saira Abbas, M. Shah, Autif Hussain Mangi, S. Ullah, Abdu Razzaq Khan, S. Iqbal, Batab Khan, Surayia Shahab Rani
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Abstract

Free radicals alter DNA, resulting in various chronic disorders, including cancer. Herbal therapy has a significant potential to block cancer progression and other chronic diseases. The Tamarix aphylla plays an essential role in the modulation of free radicals. Calotropis procera (leaves), a tropical medicinal plant, has shown protective effects against cancer progression. We have examined the antioxidant therapy of separate or combined forms of the Tamarix aphylla and Calotropis procera plant extracts. Tamarix aphylla demonstrated scavenging activity at various concentrations, including 100 microgram/ml, 500 microgram/ml, and 1000 microgram/ml (29%, 37% and 62%). The scavenging activity of Calotropis procera at various concentrations (100 microgram/ml, 500 microgram/ml, and 1000 microgram/ml) was 20%, 31% and 40% against the standard of ascorbic acid (65%, 77% and 84%). The mixture of both plant extracts displayed significant antioxidant potential at various concentrations 100 microgram/ml, 500 microgram/ml, and 1000 microgram/ml which were 45%, 64% and 78%. Our study showed that the mixture of both plants has a significant antioxidant potential by comparing individual plant extracts. Further studies are recommended to elucidate the anti-cancer potential of both plant extracts mixture using in vivo approach for tumor models.
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杨梅与牛角柳比较及联合抗氧化潜力的评价
自由基改变DNA,导致各种慢性疾病,包括癌症。草药疗法在阻止癌症进展和其他慢性疾病方面具有重要的潜力。柽柳在自由基的调节中起着重要作用。一种热带药用植物Calotropis procera(叶子)已显示出对癌症进展的保护作用。我们研究了柽柳和牛角柳植物提取物的单独或组合形式的抗氧化治疗。柽柳在100微克/毫升、500微克/毫升和1000微克/毫升的浓度下均表现出清除活性(分别为29%、37%和62%)。不同浓度(100 μ g /ml、500 μ g /ml和1000 μ g /ml)对抗坏血酸的清除率分别为20%、31%和40%,而抗坏血酸标准浓度为65%、77%和84%。两种植物提取物在100、500和1000微克/ml浓度下均表现出显著的抗氧化能力,分别为45%、64%和78%。我们的研究表明,通过比较单个植物提取物,两种植物的混合物具有显著的抗氧化潜力。建议进一步研究这两种植物提取物混合物在肿瘤模型体内的抗癌潜力。
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