Pub Date : 2023-06-30DOI: 10.38106/lmrj.2023.5.2-06
Nabeela Channar, A. Dayo, M. Ghoto, Syed Mubashir Shah, Kanwal Zaman
Asthma is a respiratory disorder prevalent in around 15% population of Pakistan. The global prevalence of asthma varies widely from country to country, however, ranges between 4.3%- 8.6%. The factors aggravating asthma in urban areas are well established. Still, there is limited data available from rural areas for the pattern of asthma, its aggravating factors and its association with family history. Therefore, this study was conducted to evaluate these factors. This descriptive and cross-sectional study was conducted in outdoor patient departments (OPD) of hospitals in Tando Adam, Sindh, Pakistan. In this study, 300 asthmatic patients were included. A non-probability convenient sampling method was adopted, and data was collected by filling a pre-designed structured proforma. The data showed that male patients were predominate with a rate of 56% as compared to 44% of females. Age and family history was not significantly associated with asthma. However factors environmental pollutants and smoking mainly associated with asthma. Quaderple therapy was most frequently prescribed method of treatment. Further studies with long term term follow-up will be required to confirm findings of this study.
{"title":"EVALUATION OF ASTHMA: AGGRAVATING FACTORS AND FAMILY HISTORY- A PRO-SPECTIVE OBSERVATIONAL STUDY","authors":"Nabeela Channar, A. Dayo, M. Ghoto, Syed Mubashir Shah, Kanwal Zaman","doi":"10.38106/lmrj.2023.5.2-06","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.2-06","url":null,"abstract":"Asthma is a respiratory disorder prevalent in around 15% population of Pakistan. The global prevalence of asthma varies widely from country to country, however, ranges between 4.3%- 8.6%. The factors aggravating asthma in urban areas are well established. Still, there is limited data available from rural areas for the pattern of asthma, its aggravating factors and its association with family history. Therefore, this study was conducted to evaluate these factors. This descriptive and cross-sectional study was conducted in outdoor patient departments (OPD) of hospitals in Tando Adam, Sindh, Pakistan. In this study, 300 asthmatic patients were included. A non-probability convenient sampling method was adopted, and data was collected by filling a pre-designed structured proforma. The data showed that male patients were predominate with a rate of 56% as compared to 44% of females. Age and family history was not significantly associated with asthma. However factors environmental pollutants and smoking mainly associated with asthma. Quaderple therapy was most frequently prescribed method of treatment. Further studies with long term term follow-up will be required to confirm findings of this study.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"253 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123285657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.38106/lmrj.2023.5.2-01
B. Syed
Ageing is a physiological phenomenon; all living beings in the universe are born with a default setting. Ageing is associated with several morbidities, chronic illness, and eventual demise. For a long time, ageing was thought to be a genetic portent, but recent research suggests more epigenetic involvement. Animal model research has shown successful reversal of ageing. Remodelling of the genome to the younger age will likely eliminate senile diseases.
{"title":"AGE REVERSAL- A NEW PARADIGM SHIFT IN MEDICAL SCIENCES","authors":"B. Syed","doi":"10.38106/lmrj.2023.5.2-01","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.2-01","url":null,"abstract":"Ageing is a physiological phenomenon; all living beings in the universe are born with a default setting. Ageing is associated with several morbidities, chronic illness, and eventual demise. For a long time, ageing was thought to be a genetic portent, but recent research suggests more epigenetic involvement. Animal model research has shown successful reversal of ageing. Remodelling of the genome to the younger age will likely eliminate senile diseases.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127321477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.38106/lmrj.2023.5.2-08
Zia Ahmed Shaikh, Azar Akbar Memon, A. M. Shaikh, Samiullah Soomro, Mehran Sayed
Medical data management presents significant challenges in terms of security, privacy, and efficiency. Blockchain technology has emerged as a promising solution to address these concerns in recent years. This comprehensive review explores the role of blockchain technology in secure and efficient medical data management. By providing a decentralized and immutable ledger, blockchain ensures data integrity, enhances privacy, and facilitates auditable access to medical information. The paper examines various applications of blockchain in medical data management, including electronic health records (EHRs), medical imaging, clinical trials, telemedicine, and drug supply chain management. It highlights the benefits and challenges of implementing blockchain in healthcare settings, discussing interoperability, consent management, scalability, and regulatory considerations. The review encompasses relevant research studies, industry initiatives, and real-world use cases to provide a comprehensive overview of the current state of blockchain technology in medical data management. The paper concludes with a discussion of future directions and potential areas for further research, emphasizing the transformative potential of blockchain in revolutionizing the way of medical data storage, sharing, and utilization.
{"title":"BLOCKCHAIN IN HEALTHCARE: UNLOCKING THE POTENTIAL OF BLOCKCHAIN FOR SECURE AND EFFICIENT APPLICATIONS FOR MEDICAL DATA MANAGEMENT- A PRESENTATION OF BASIC CONCEPTS","authors":"Zia Ahmed Shaikh, Azar Akbar Memon, A. M. Shaikh, Samiullah Soomro, Mehran Sayed","doi":"10.38106/lmrj.2023.5.2-08","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.2-08","url":null,"abstract":"Medical data management presents significant challenges in terms of security, privacy, and efficiency. Blockchain technology has emerged as a promising solution to address these concerns in recent years. This comprehensive review explores the role of blockchain technology in secure and efficient medical data management. By providing a decentralized and immutable ledger, blockchain ensures data integrity, enhances privacy, and facilitates auditable access to medical information. The paper examines various applications of blockchain in medical data management, including electronic health records (EHRs), medical imaging, clinical trials, telemedicine, and drug supply chain management. It highlights the benefits and challenges of implementing blockchain in healthcare settings, discussing interoperability, consent management, scalability, and regulatory considerations. The review encompasses relevant research studies, industry initiatives, and real-world use cases to provide a comprehensive overview of the current state of blockchain technology in medical data management. The paper concludes with a discussion of future directions and potential areas for further research, emphasizing the transformative potential of blockchain in revolutionizing the way of medical data storage, sharing, and utilization.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124587668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.38106/lmrj.2023.5.2-09
Anny Ashiq Ali, S. Nazim, A. Khan
Cardiomyopathies are a group of diseases characterized by the structural and functional abnormalities of the heart muscles in the absence of other illnesses that might be responsible for the observed myocardial anomaly. Hypertrophic and dilated cardiomyopathies are the most prevalent types. Rare types include restrictive cardiomyopathy and restrictive cardiomyopathy with arrhythmia. Dilated cardiomyopathy has a documented prevalence of 36 cases per 100,000 population in Europe and North America, and its yearly incidence varies between 5 and 7.9 cases per 100,000 population. Non-ischemic dilated cardiomyopathy, which causes heart failure, dramatically increases the global burden of cardiovascular diseases. For both men and women, acute dilated cardiomyopathy is mainly brought on by myocarditis. This case was present in Aga Khan University Hospital; and was selected to be reported. The diagnosis in the case scenario is non-ischemic cardiomyopathy associated with heart failure and pulmonary oedema.
{"title":"NON ISCHEMIC CARDIOMYOPATHY – A CASE REPORT","authors":"Anny Ashiq Ali, S. Nazim, A. Khan","doi":"10.38106/lmrj.2023.5.2-09","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.2-09","url":null,"abstract":"Cardiomyopathies are a group of diseases characterized by the structural and functional abnormalities of the heart muscles in the absence of other illnesses that might be responsible for the observed myocardial anomaly. Hypertrophic and dilated cardiomyopathies are the most prevalent types. Rare types include restrictive cardiomyopathy and restrictive cardiomyopathy with arrhythmia. Dilated cardiomyopathy has a documented prevalence of 36 cases per 100,000 population in Europe and North America, and its yearly incidence varies between 5 and 7.9 cases per 100,000 population. Non-ischemic dilated cardiomyopathy, which causes heart failure, dramatically increases the global burden of cardiovascular diseases. For both men and women, acute dilated cardiomyopathy is mainly brought on by myocarditis. This case was present in Aga Khan University Hospital; and was selected to be reported. The diagnosis in the case scenario is non-ischemic cardiomyopathy associated with heart failure and pulmonary oedema.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128892003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.38106/lmrj.2023.5.2-07
Mehran Sayed, Shoaib Wadho, Azar Akbar Memon, A. M. Shaikh, Zia Ahmed Shaikh
This review discussed augmented reality (AR), a new emerging technology seen everywhere in our daily lives. Augmented reality is widely used in healthcare, advertising, and engineering industries. It seems like the world will combine the real and the virtual worlds. From an educational perspective, augmented reality allows multimedia materials. This review aimed to provide reported trends and critical synthesis to identify gaps in existing literature and research areas. The PubMed, Web of Science, and Discover databases were used as sources for the review of the literature. This review included published studies reported in peer-reviewed research journals between 2019 to 2021. Augmented reality-based learning programs are widely used in medical schools around the globe because it provides distinct learning sources, such as remote learning and simulation-based learning. The benefits have increased in the recent COVID-19 pandemic, making it possible to give online. Education systems, including medical institutions, used augmented reality for the experiments and training of their students. This review also discussed how AR can improve the knowledge and skills of medical students.
本文讨论了增强现实(AR)，这是一项在我们日常生活中随处可见的新兴技术。增强现实广泛应用于医疗保健、广告和工程行业。似乎这个世界将把真实世界和虚拟世界结合起来。从教育的角度来看，增强现实允许多媒体材料。本综述旨在提供报告的趋势和关键的综合，以确定现有文献和研究领域的差距。PubMed、Web of Science和Discover数据库被用作文献综述的来源。该综述包括2019年至2021年在同行评议的研究期刊上发表的研究报告。基于增强现实的学习计划在全球医学院广泛使用，因为它提供了不同的学习来源，例如远程学习和基于模拟的学习。在最近的COVID-19大流行期间，这些好处有所增加，使得在线捐赠成为可能。包括医疗机构在内的教育系统使用增强现实技术进行实验和培训学生。本文还讨论了AR如何提高医学生的知识和技能。
{"title":"SUCCEEDING GENERATION OF AUGMENTED REALITY TECHNOLOGY IN MEDICAL EDUCATION","authors":"Mehran Sayed, Shoaib Wadho, Azar Akbar Memon, A. M. Shaikh, Zia Ahmed Shaikh","doi":"10.38106/lmrj.2023.5.2-07","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.2-07","url":null,"abstract":"This review discussed augmented reality (AR), a new emerging technology seen everywhere in our daily lives. Augmented reality is widely used in healthcare, advertising, and engineering industries. It seems like the world will combine the real and the virtual worlds. From an educational perspective, augmented reality allows multimedia materials. This review aimed to provide reported trends and critical synthesis to identify gaps in existing literature and research areas. The PubMed, Web of Science, and Discover databases were used as sources for the review of the literature. This review included published studies reported in peer-reviewed research journals between 2019 to 2021. Augmented reality-based learning programs are widely used in medical schools around the globe because it provides distinct learning sources, such as remote learning and simulation-based learning. The benefits have increased in the recent COVID-19 pandemic, making it possible to give online. Education systems, including medical institutions, used augmented reality for the experiments and training of their students. This review also discussed how AR can improve the knowledge and skills of medical students.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115574238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.38106/lmrj.2023.5.2-02
Shahid Khan, Fahim-ullah Khan, Saira Abbas, M. Shah, Autif Hussain Mangi, S. Ullah, Abdu Razzaq Khan, S. Iqbal, Batab Khan, Surayia Shahab Rani
Free radicals alter DNA, resulting in various chronic disorders, including cancer. Herbal therapy has a significant potential to block cancer progression and other chronic diseases. The Tamarix aphylla plays an essential role in the modulation of free radicals. Calotropis procera (leaves), a tropical medicinal plant, has shown protective effects against cancer progression. We have examined the antioxidant therapy of separate or combined forms of the Tamarix aphylla and Calotropis procera plant extracts. Tamarix aphylla demonstrated scavenging activity at various concentrations, including 100 microgram/ml, 500 microgram/ml, and 1000 microgram/ml (29%, 37% and 62%). The scavenging activity of Calotropis procera at various concentrations (100 microgram/ml, 500 microgram/ml, and 1000 microgram/ml) was 20%, 31% and 40% against the standard of ascorbic acid (65%, 77% and 84%). The mixture of both plant extracts displayed significant antioxidant potential at various concentrations 100 microgram/ml, 500 microgram/ml, and 1000 microgram/ml which were 45%, 64% and 78%. Our study showed that the mixture of both plants has a significant antioxidant potential by comparing individual plant extracts. Further studies are recommended to elucidate the anti-cancer potential of both plant extracts mixture using in vivo approach for tumor models.
自由基改变DNA，导致各种慢性疾病，包括癌症。草药疗法在阻止癌症进展和其他慢性疾病方面具有重要的潜力。柽柳在自由基的调节中起着重要作用。一种热带药用植物Calotropis procera(叶子)已显示出对癌症进展的保护作用。我们研究了柽柳和牛角柳植物提取物的单独或组合形式的抗氧化治疗。柽柳在100微克/毫升、500微克/毫升和1000微克/毫升的浓度下均表现出清除活性(分别为29%、37%和62%)。不同浓度(100 μ g /ml、500 μ g /ml和1000 μ g /ml)对抗坏血酸的清除率分别为20%、31%和40%，而抗坏血酸标准浓度为65%、77%和84%。两种植物提取物在100、500和1000微克/ml浓度下均表现出显著的抗氧化能力，分别为45%、64%和78%。我们的研究表明，通过比较单个植物提取物，两种植物的混合物具有显著的抗氧化潜力。建议进一步研究这两种植物提取物混合物在肿瘤模型体内的抗癌潜力。
{"title":"THE ASSESSMENT OF TAMARIX APHYLLA AND CALOTROPIS PROCERA COMPARATIVE AND COMBINE ANTIOXIDANT POTENTIAL","authors":"Shahid Khan, Fahim-ullah Khan, Saira Abbas, M. Shah, Autif Hussain Mangi, S. Ullah, Abdu Razzaq Khan, S. Iqbal, Batab Khan, Surayia Shahab Rani","doi":"10.38106/lmrj.2023.5.2-02","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.2-02","url":null,"abstract":"Free radicals alter DNA, resulting in various chronic disorders, including cancer. Herbal therapy has a significant potential to block cancer progression and other chronic diseases. The Tamarix aphylla plays an essential role in the modulation of free radicals. Calotropis procera (leaves), a tropical medicinal plant, has shown protective effects against cancer progression. We have examined the antioxidant therapy of separate or combined forms of the Tamarix aphylla and Calotropis procera plant extracts. Tamarix aphylla demonstrated scavenging activity at various concentrations, including 100 microgram/ml, 500 microgram/ml, and 1000 microgram/ml (29%, 37% and 62%). The scavenging activity of Calotropis procera at various concentrations (100 microgram/ml, 500 microgram/ml, and 1000 microgram/ml) was 20%, 31% and 40% against the standard of ascorbic acid (65%, 77% and 84%). The mixture of both plant extracts displayed significant antioxidant potential at various concentrations 100 microgram/ml, 500 microgram/ml, and 1000 microgram/ml which were 45%, 64% and 78%. Our study showed that the mixture of both plants has a significant antioxidant potential by comparing individual plant extracts. Further studies are recommended to elucidate the anti-cancer potential of both plant extracts mixture using in vivo approach for tumor models.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134000924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.38106/lmrj.2023.5.2-04
Adnan Iqbal, Rahila Najam, A. Ishaqui, Fatima Rehman, Jameela Jamali, S. Ahmed, Lailoona Jawed, Muhammad Imran, I. Khan, A. M. Shaikh, Shayan Ahmed, Z. Ahmed
Hyponatremia and hyperglycemia are common metabolic disorders which could worsen the outcome after a cerebrovascular accident (stroke). This study aimed to evaluate the impact of hyponatremia and hyperglycemia on stroke and its clinical outcome, including morbidity and mortality. This prospective cohort study included 50 stroke patients admitted in tertiary care hospitals. Stroke severity, Glasgow coma scale (GCS), conscious level, gag reflex, clinical presentations, and outcomes were recorded. Following a stroke, patients were monitored for a period of six months, during which the patient's death was recorded on the event form. Linear logistic regression model was used to determine the stroke mortality. Hyponatremia and hyperglycaemia were associated with higher odds ratio of deaths, poor functional recovery, severe disability, low mean GCS score as compared to normonatremic and normoglycemic patients (odds ratio [OR] = 4.7; 95% CI= 0.929-43.782) and hyperglycaemia (OR= 2.74; 95% CI=0.577-13.03). Stroke patients admitted with hyperglycemia or hyponatremia were associated with greater morbidity and mortality and poor functional recovery.
{"title":"EVALUATION OF IMPACT OF HYPERGLYCEMIA AND HYPONATREMIA ON CLINICAL OUT-COME OF ACUTE STROKE","authors":"Adnan Iqbal, Rahila Najam, A. Ishaqui, Fatima Rehman, Jameela Jamali, S. Ahmed, Lailoona Jawed, Muhammad Imran, I. Khan, A. M. Shaikh, Shayan Ahmed, Z. Ahmed","doi":"10.38106/lmrj.2023.5.2-04","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.2-04","url":null,"abstract":"Hyponatremia and hyperglycemia are common metabolic disorders which could worsen the outcome after a cerebrovascular accident (stroke). This study aimed to evaluate the impact of hyponatremia and hyperglycemia on stroke and its clinical outcome, including morbidity and mortality.\u0000This prospective cohort study included 50 stroke patients admitted in tertiary care hospitals. Stroke severity, Glasgow coma scale (GCS), conscious level, gag reflex, clinical presentations, and outcomes were recorded. Following a stroke, patients were monitored for a period of six months, during which the patient's death was recorded on the event form. Linear logistic regression model was used to determine the stroke mortality. Hyponatremia and hyperglycaemia were associated with higher odds ratio of deaths, poor functional recovery, severe disability, low mean GCS score as compared to normonatremic and normoglycemic patients (odds ratio [OR] = 4.7; 95% CI= 0.929-43.782) and hyperglycaemia (OR= 2.74; 95% CI=0.577-13.03). Stroke patients admitted with hyperglycemia or hyponatremia were associated with greater morbidity and mortality and poor functional recovery.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114780722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Corona Virus Disease (COVID-19) was reported for the first time in 2019 as acute respiratory syndrome. However, its effects on other systems also became evident. Acute kidney injury (AKI) is the typical manifestation of renal involvement, reported in several cases; nevertheless, there is a lack of consensus regarding AKI manifestations of COVID-19. Therefore, this study was designed to determine the frequency of AKI in Pakistani patients presenting with severe COVID-19. It was a descriptive cross-sectional study conducted at the Department of Nephrology, Liaquat University of Medical and Health Sciences, Jamshoro, over a period of six months from 1 January 2022 to 30 June 2022. A total of 113 patients were included, who fulfilled pre-defined inclusion criteria. Acute renal injury was assessed using acute kidney injury based on the 2012 KIGDO AKI criteria. The mean age of our study's participants was 45.72 years, and of the 113 participants, 49 (43.4%) were male and 64 (56.6%) were female patients. Twenty-eight (24.8%) had diabetes, and thirty-four (30.1%) were hypertensive. 59 (52.2%) patients were found to have AKI. Age, gender, diabetes, hypertension and the severity of COVID-19 did not show any significant association with AKI. Acute kidney injury was found in a considerable number of COVID-19 patients. Therefore, close monitoring of patients must be done in all patients with regular follow-up.
{"title":"ACUTE KIDNEY INJURY IN PATIENTS PRESENTING WITH SEVERE COVID-19 - A DESCRIP-TIVE STUDY","authors":"Iram Ashraf, P. Mal, Javed Altaf Jat, Mukesh Kumar, Sunil Gurbukshani, Aqsa Fatima, Khashia Tahir","doi":"10.38106/lmrj.2023.5.2-03","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.2-03","url":null,"abstract":"The Corona Virus Disease (COVID-19) was reported for the first time in 2019 as acute respiratory syndrome. However, its effects on other systems also became evident. Acute kidney injury (AKI) is the typical manifestation of renal involvement, reported in several cases; nevertheless, there is a lack of consensus regarding AKI manifestations of COVID-19. Therefore, this study was designed to determine the frequency of AKI in Pakistani patients presenting with severe COVID-19. It was a descriptive cross-sectional study conducted at the Department of Nephrology, Liaquat University of Medical and Health Sciences, Jamshoro, over a period of six months from 1 January 2022 to 30 June 2022. A total of 113 patients were included, who fulfilled pre-defined inclusion criteria. Acute renal injury was assessed using acute kidney injury based on the 2012 KIGDO AKI criteria. The mean age of our study's participants was 45.72 years, and of the 113 participants, 49 (43.4%) were male and 64 (56.6%) were female patients. Twenty-eight (24.8%) had diabetes, and thirty-four (30.1%) were hypertensive. 59 (52.2%) patients were found to have AKI. Age, gender, diabetes, hypertension and the severity of COVID-19 did not show any significant association with AKI. Acute kidney injury was found in a considerable number of COVID-19 patients. Therefore, close monitoring of patients must be done in all patients with regular follow-up.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125694478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-27DOI: 10.38106/lmrj.2023.5.1.07
Javed Altaf Jatt, W. Memon, Muhammad Murtaza Azad, Muhammad Iqbal Naseem, Sana Tariq
Unilateral multicystic dysplastic kidney (MCDK) is congenital anomaly which can be detected by ultrasound during antenatal period. The reported rate of MCDK ranges between 1 in 2,200 to 1 in 4,300 live births. This study was aimed to assess the determinants associated with the MCDK with follow-up until teens to evaluate the evolution of the disorder. This was an observational longitudinal study, involution degrees were observed following the baseline measurement of the size of the MCDK as documented on postnatal ultrasound, and long-term complications and renal function were also recorded. A total of 350 patients were identified, while 90 patients fulfilled the criteria of the study and completed the study duration of 10 years. Out of which 19 (21.1%) patients reported involution of MCDK size during follow-up as complete and partial, 7 (7.7%) within first year of age, 5 (5.5%) during first 2 years and 7 (7.7%) within 4 years of age. Large-sized MCDK at the time of diagnosis is less likely to involute through the first decade of life. However, conventional treatment is rational with the absence of complications.
{"title":"Involution of unilateral multicystic dysplastic kidney: Long term data from a single centre","authors":"Javed Altaf Jatt, W. Memon, Muhammad Murtaza Azad, Muhammad Iqbal Naseem, Sana Tariq","doi":"10.38106/lmrj.2023.5.1.07","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.1.07","url":null,"abstract":"Unilateral multicystic dysplastic kidney (MCDK) is congenital anomaly which can be detected by ultrasound during antenatal period. The reported rate of MCDK ranges between 1 in 2,200 to 1 in 4,300 live births. This study was aimed to assess the determinants associated with the MCDK with follow-up until teens to evaluate the evolution of the disorder. This was an observational longitudinal study, involution degrees were observed following the baseline measurement of the size of the MCDK as documented on postnatal ultrasound, and long-term complications and renal function were also recorded. A total of 350 patients were identified, while 90 patients fulfilled the criteria of the study and completed the study duration of 10 years. Out of which 19 (21.1%) patients reported involution of MCDK size during follow-up as complete and partial, 7 (7.7%) within first year of age, 5 (5.5%) during first 2 years and 7 (7.7%) within 4 years of age. Large-sized MCDK at the time of diagnosis is less likely to involute through the first decade of life. However, conventional treatment is rational with the absence of complications.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"24 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132538919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Coronavirus Disease 2019 (COVID-19) has adversely affected the global healthcare system, especially the management of surgical diseases. Most guidelines issued during pandemic recommended deferral of elective surgeries to decrease transmission and conserve resources for COVID-19 management, which raised the risk of complications. This study was conducted to evaluate the impact of the COVID-19 pandemic on the general surgical practice of a tertiary healthcare facility in Sindh, Pakistan. The data were retrospectively retrieved from the operation room records for most common general surgical procedures performed between January 2019 to December 2020 (i.e. peak COVID-19 restriction period). Monthly frequencies of the enrolled procedures were compared to COVID-19-associated incidence, recoveries, and mortality in Sindh. The six enrolled procedures suffered a reduction of 23.9% from 2019 to 2020. However, the difference was not significant (p >0.05) for the procedures collectively or individually, except for trucut biopsy (p =0.042). COVID-19-associated mortality significantly influences the frequency of the surgical procedures, compared to the pre-COVID era (p =0.042). However, the association was significant for the procedures collectively only, but in the individual procedure, only open inguinal hernia repair (p =0.011) showed a significant difference. In conclusion, there was a significant reduction in surgical cases with the potential risk of complications. Therefore in such situations, there must be a developed system to that the cases may be decided on an individual basis.
{"title":"Impact of COVID-19 pandemic on general surgical practice at tertiary care hospital in Pakistan - A single center analysis","authors":"Omema Saleem, Umm-e Habiba Abdul Rauf, Mujeeb Rehman Malik, Karim Rizwan Nathani, Faisal Ghani Siddiqui","doi":"10.38106/lmrj.2023.5.1.02","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.1.02","url":null,"abstract":"The Coronavirus Disease 2019 (COVID-19) has adversely affected the global healthcare system, especially the management of surgical diseases. Most guidelines issued during pandemic recommended deferral of elective surgeries to decrease transmission and conserve resources for COVID-19 management, which raised the risk of complications. This study was conducted to evaluate the impact of the COVID-19 pandemic on the general surgical practice of a tertiary healthcare facility in Sindh, Pakistan. The data were retrospectively retrieved from the operation room records for most common general surgical procedures performed between January 2019 to December 2020 (i.e. peak COVID-19 restriction period). Monthly frequencies of the enrolled procedures were compared to COVID-19-associated incidence, recoveries, and mortality in Sindh. The six enrolled procedures suffered a reduction of 23.9% from 2019 to 2020. However, the difference was not significant (p >0.05) for the procedures collectively or individually, except for trucut biopsy (p =0.042). COVID-19-associated mortality significantly influences the frequency of the surgical procedures, compared to the pre-COVID era (p =0.042). However, the association was significant for the procedures collectively only, but in the individual procedure, only open inguinal hernia repair (p =0.011) showed a significant difference. In conclusion, there was a significant reduction in surgical cases with the potential risk of complications. Therefore in such situations, there must be a developed system to that the cases may be decided on an individual basis.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131850969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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