Biochemical alterations associated with experimentally induced breast cancer in rats

Abstract

This study was conducted to demonstrate the preventive graviola effect on breast cancer induced by 7,12-dimethylbenz [a] anthracene (DMBA) in fifty female rats distributed into four groups. Group I: Control group injected orally by physiological saline, group II: DMBA induced-breast cancer, injected orally a single dose of DMBA (50mg/kg) diluted in sesame oil (1 ml), group III: Graviola 200 mg/kg two times per week given orally by gavage from the first day of the experiment till the end plus a single dose of DMBA (50mg/kg) diluted in sesame oil (1mL) given orally at age of 57 days and group IV: rats treated with single dose of DMBA (50mg/kg) diluted in sesame oil (1mL) given orally plus graviola 200 mg/kg two times weekly both at age of 57 days till the end. After 30w the animals were anaesthetized to collect blood samples to determine the hepatic and renal protection of graviola. Treatment with graviola significantly (p< 0.05) reduced ALT activity and creatinine level. We can conclude that graviola mitigated hepatic and kidney functions.