{"title":"Biodegradation of Poly(alkylcyanoacrylates)","authors":"C. Vauthier, P. Couvreur","doi":"10.1002/3527600035.BPOL9021","DOIUrl":null,"url":null,"abstract":"Introduction \nHistorical Outline \nSynthesis and Purification of Alkylcyanoacrylate Monomers \nPolymer Synthesis \nGeneral Considerations \nBulk Polymerization \nPolymerization in Organic Solvents \nEmulsion Polymerization: Preparation of Matricial PACA Nanoparticles (Nanospheres) \nInterfacial Polymerization: Preparation of Reservoir-Type PACA Nanoparticles (Nanocapsules) \nSynthesis of Amphiphilic Block Copolymers Containing PACA Segments \nWorld Market \n \n \nCharacterization and Methods of Analysis \nStability and Mechanism of Degradation \nToxicity \nApplication of PACA in the Design of Drug Delivery Systems \nUse of “Conventional” PACA Nanoparticles \nFrom “Conventional” to Targeted Systems \n \n \nPatent Overview \nOutlook and Perspectives \n \n \nKeywords: \n \nalkylcyanoacrylate; \nanionic polymerization; \ncancer; \ncopolymer; \ndegradation; \ndrug delivery system; \nnanocapsule; \nnanoparticle; \nnanosphere; \nocular; \noligonucleotide; \npeptide; \npoly(alkylcyanoacrylate); \npoly(ethylene glycol); \nprotein; \nradical polymerization; \ntoxicity; \nzwitterionic polymerization","PeriodicalId":165163,"journal":{"name":"Biopolymers Online","volume":"26 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2002-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biopolymers Online","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/3527600035.BPOL9021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Introduction
Historical Outline
Synthesis and Purification of Alkylcyanoacrylate Monomers
Polymer Synthesis
General Considerations
Bulk Polymerization
Polymerization in Organic Solvents
Emulsion Polymerization: Preparation of Matricial PACA Nanoparticles (Nanospheres)
Interfacial Polymerization: Preparation of Reservoir-Type PACA Nanoparticles (Nanocapsules)
Synthesis of Amphiphilic Block Copolymers Containing PACA Segments
World Market
Characterization and Methods of Analysis
Stability and Mechanism of Degradation
Toxicity
Application of PACA in the Design of Drug Delivery Systems
Use of “Conventional” PACA Nanoparticles
From “Conventional” to Targeted Systems
Patent Overview
Outlook and Perspectives
Keywords:
alkylcyanoacrylate;
anionic polymerization;
cancer;
copolymer;
degradation;
drug delivery system;
nanocapsule;
nanoparticle;
nanosphere;
ocular;
oligonucleotide;
peptide;
poly(alkylcyanoacrylate);
poly(ethylene glycol);
protein;
radical polymerization;
toxicity;
zwitterionic polymerization
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