[Relation between the anti-oxidative potential of psoriasis blood plasma in reactivity of granulocytes].

Abstract

It was revealed a positive correlation between an antioxidative potential (AP) of blood plasma from psoriasis patients and generation of O2- by normal granulocytes, stimulated by zymosan or aggregated human gamma-globulin, in the presence of the same plasma samples. The AP of plasma was measured by means of inhibition of the chemiluminescence arising during photoautoxidation of luminol. The production of O2- after cell stimulation was estimated by means of the reduction of tetrazolium salt. The result is discussed from the viewpoint of informative-regulatory role of the plasma AP for the white blood cells as a part of the whole organism, participating in its common defence reactions.