Dermatologische Monatschrift最新文献

Described are two drug eruptions from talastine hydrochloride (Ahanon). To the best of our knowledge these are the first published allergic exanthemas due to this antihistamine.

In a man aged 29 following thyroidectomy complicated by myxoedema an onychomycotic infection of long duration spread suddenly and fast onto the skin. A serious traffic accident coincided with the insidious onset of myxoedema. The patient was very irregular in taking medicines and continuously on sick pay. Myxoedema worsened and the ringworm progressed into a generalized ichthyosiform--universal mycotic--condition.

A report is given on 4 cases of Ecthyma contagiosum (Orf). Orf is caused by a poxvirus and often it is acquired professionally by direct inoculation from infected sheep.

In previous immunohistochemical studies calmodulin (CaM) was detected in the sweat duct. In further investigations we searched for CaM-reactivity in eccrine poromas and clear cell acanthomas. CaM was only detectable in whorl-like areas, so confirming the concept of a ductal origin of this tumor. CaM-reactivity was failing in both, intraepidermal and malignant eccrine poroma. Acanthomas with clear cell pattern failed to give uniform results, suggesting a heterogenous origin of clear cells in the tumours investigated.

Reexamination of ANA positive sera with nucleolare fluorescence staining on HEp-2 cells and hamster liver imprints revealed 3 sera with an uniform characteristic pattern. It is characterized by: 1. Strong clumpy fluorescence of nucleoli in the interphase. 2. Missing nucleoplasma staining (pure nucleolar). 3. Characteristic granular staining of the cytoplasma from the condensed chromosoma in mitosis. 4. Additive fluorescence of a nucleolus-like body. 5. Extremely high antibody titers. 6. Negative immunodiffusion. This nucleolar staining pattern was described by Bernstein et al. as a clumpy nucleolar pattern. It is produced through an antibody to the dense fibrillar component of the nucleolus (fibrillarin). This antigen is a protein of the U3 RNP with a molecular weight 34 kDa. Clinically is the fibrillarin antibody highly specific for systemic scleroderma especially with diffuse skin involvement. We found it in 1% of scleroderma patients. Its pathogenetic importance is not known.

In a pilot study the antimycetic effect of the lectin anti-AHP in 40 patients suffering from different mycoses was studied. The treatment with an aqueous solution of anti-AHP resulted in a complete healing in 15 of 40 cases and in 16 patients in a remarkable improvement, whereas in 9 cases such an effect has not been observed. The mode of operations remains still unknown, possible actions of anti-AHP on fungi and stratum corneum are discussed.

We report on a nevus of the oral mucosa, which became present in the age of 30 of a male patient. By microscopic examination we did not find any vacuolation of the spinous layer of the epithelium. So this nevus has been considered quite different from the typical white sponge nevus, and we prefer to name it leucoplakial nevus of the oral mucosa.

The clinical application of cyclosporine A caused many success in transplantation surgery as well as in the treatment of (auto-) immune disorders. The biological highly active substance differs from conventional immunosuppressive drugs (i.e. steroids, azathioprine) by it's selective action on T-lymphocytes. However, current experimental findings indicate a direct influence on epidermal keratinocytes, too. First therapeutical experiences, concerning systemic and topical application in different skin diseases are summarized.