One new prenylated flavonoid with cytotoxic activity from Epimedium brevicornu maxim

IF 1.9 3区 化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-02-16 DOI:10.1080/14786419.2023.2282114
Hui Zhang , YanRu Wang , Yuhang Liang , Xu Zhao , Gang Chen
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Abstract

One previously undescribed prenylated flavonoid (1) and three known ones (2-4) were isolated from leaves of Epimedium brevicornu maxim. Their structures were determined through extensive spectroscopic analysis and comparison with the NMR data in the literature. Compound 1 showed a moderate cytotoxicity with an IC50 value of 18.7 μM, while known compounds 2 and 3 elicited weak cytotoxicities with IC50 values of 29.2 and 32.8 μM against Lewis Lung cancer cells (LLC cells), respectively.
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短草淫羊藿中一个新的具有细胞毒活性的烯丙基类黄酮。
从淫羊藿(Epimedium brevicornu maxim)叶片中分离到1个未被描述的烯丙化类黄酮(1)和3个已知的类黄酮(2-4)。它们的结构是通过广泛的光谱分析和与文献中的核磁共振数据比较确定的。化合物1对Lewis肺癌细胞(LLC细胞)具有中等毒性,IC50值为18.7 μM,而已知化合物2和3对Lewis肺癌细胞具有较弱的细胞毒性,IC50值分别为29.2和32.8 μM。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Natural Product Research
Natural Product Research 化学-医药化学
CiteScore
5.10
自引率
9.10%
发文量
605
审稿时长
2.1 months
期刊介绍: The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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