Hui Zhang , YanRu Wang , Yuhang Liang , Xu Zhao , Gang Chen
{"title":"One new prenylated flavonoid with cytotoxic activity from Epimedium brevicornu maxim","authors":"Hui Zhang , YanRu Wang , Yuhang Liang , Xu Zhao , Gang Chen","doi":"10.1080/14786419.2023.2282114","DOIUrl":null,"url":null,"abstract":"<div><div>One previously undescribed prenylated flavonoid (<strong>1</strong>) and three known ones (<strong>2-4</strong>) were isolated from leaves of <em>Epimedium brevicornu</em> maxim. Their structures were determined through extensive spectroscopic analysis and comparison with the NMR data in the literature. Compound <strong>1</strong> showed a moderate cytotoxicity with an IC<sub>50</sub> value of 18.7 μM, while known compounds <strong>2</strong> and <strong>3</strong> elicited weak cytotoxicities with IC<sub>50</sub> values of 29.2 and 32.8 μM against Lewis Lung cancer cells (LLC cells), respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 981-984"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641923022702","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
One previously undescribed prenylated flavonoid (1) and three known ones (2-4) were isolated from leaves of Epimedium brevicornu maxim. Their structures were determined through extensive spectroscopic analysis and comparison with the NMR data in the literature. Compound 1 showed a moderate cytotoxicity with an IC50 value of 18.7 μM, while known compounds 2 and 3 elicited weak cytotoxicities with IC50 values of 29.2 and 32.8 μM against Lewis Lung cancer cells (LLC cells), respectively.
期刊介绍:
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.