The wonders of stem cells therapeutic application towards chronic obstructive pulmonary disease

IF 3.3 3区 医学 Q2 PHARMACOLOGY & PHARMACY Pulmonary pharmacology & therapeutics Pub Date : 2023-11-13 DOI:10.1016/j.pupt.2023.102269
Akram Tayanloo-Beik , Shayesteh Kokabi Hamidpour , Mohaddese chaharbor , Mostafa Rezaei-Tavirani , Rasta Arjmand , Hossein Adibi , Hamid Ojagh , Bagher Larijani , Babak Arjmand
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Abstract

Chronic obstructive pulmonary disease (COPD) is a respiratory condition characterized by its heterogeneous nature, progressive course, and significant impact on individuals' quality of life. It is a prevalent global health issue affecting a substantial number of individuals and can pose life-threatening complications if left unmanaged. The development and course of COPD can be influenced by a range of risk factors, including genetic predisposition and environmental exposures. Nevertheless, as researchers adopt a more comprehensive and expansive viewpoint of therapeutic techniques, the associated obstacles become more apparent. Indeed, a definitive medication for COPD that reliably leads to symptom alleviation has not yet been discovered. Therefore, the limitations of conventional therapy methods prompted researchers to focus on the advancement of novel procedures, potentially leading to significant outcomes. In contemporary times, the field of regenerative medicine and cell therapy has presented unprecedented opportunities for the exploration of innovative treatments for COPD, owing to the distinctive attributes exhibited by stem cells. Hence, it is imperative to provide due consideration to preclinical investigations and notable characteristics of stem cells as they serve as a means to comprehensively comprehend the fundamental mechanisms of COPD and uncover novel therapeutic strategies with enhanced efficacy for patients.

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干细胞治疗慢性阻塞性肺疾病的奇迹。
慢性阻塞性肺疾病(COPD)是一种呼吸系统疾病,其特点是异质性、进行性病程和对个体生活质量的显著影响。这是一个普遍存在的全球健康问题,影响到许多人,如果不加以控制,可能造成危及生命的并发症。慢性阻塞性肺病的发展和病程可受到一系列危险因素的影响,包括遗传易感性和环境暴露。然而,随着研究人员对治疗技术采取更全面和更广泛的观点,相关的障碍变得更加明显。事实上,目前还没有发现一种能够有效缓解COPD症状的药物。因此,传统治疗方法的局限性促使研究人员将重点放在新方法的发展上,这可能会带来显著的结果。在当代,由于干细胞所表现出的独特属性,再生医学和细胞治疗领域为探索COPD的创新治疗提供了前所未有的机会。因此,我们必须充分考虑干细胞的临床前研究和显著特征,因为它们可以全面了解COPD的基本机制,并发现新的治疗策略,提高患者的疗效。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
41
审稿时长
42 days
期刊介绍: Pulmonary Pharmacology and Therapeutics (formerly Pulmonary Pharmacology) is concerned with lung pharmacology from molecular to clinical aspects. The subject matter encompasses the major diseases of the lung including asthma, cystic fibrosis, pulmonary circulation, ARDS, carcinoma, bronchitis, emphysema and drug delivery. Laboratory and clinical research on man and animals will be considered including studies related to chemotherapy of cancer, tuberculosis and infection. In addition to original research papers the journal will include review articles and book reviews. Research Areas Include: • All major diseases of the lung • Physiology • Pathology • Drug delivery • Metabolism • Pulmonary Toxicology.
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