Emerging theragnostic molecularly imprinted nano-antibodies

Abstract

Molecularly imprinted nano-antibodies (MINAs) are tailor-made recognition synthetic antibodies that mimic the behavior of biological receptors with a central role in numerous living systems. In the last decades, MINAs have gained attention for present high selectivity and affinity, remarkable stability, effective production methods, and potentially low cost. Currently, with innovations in material science and technological breakthroughs, the applications of MINAs are eventually undergoing a revolutionary transformation from the initial separation and adsorption fields to the burgeoning biomedicine fields. In this review, a comprehensive overview of key current progress made in the preparation of MINAs and their crucial biomedical applications is presented. Also, we provide future perspectives and highlight the present challenges remaining for prospective research on the biomedical applications of MINAs. We envision that this review will provide precious guidance for constructing multifunctional MINAs tailored towards the frontier needs in biomedicines, thereby fostering the development of approaches to biological material.