Pub Date : 2026-01-26DOI: 10.1016/j.colcom.2026.100870
Paula Suárez-Vaquero , Beatriz Rodríguez , Amanda Moyano , Baihui Wang , Alberto Sánchez-Calvo , Esther Serrano-Pertierra , José María Duque , Luis Sánchez , Guillermo García-Santos , Luis García-Flórez , Gemma Gutiérrez , María Matos , María Carmen Blanco-López
Lateral flow assays (LFA) have been widely used for rapid and low-cost detection of biomolecules in a variety of fields. In this work, we have developed a LFA for potential biomarkers of colorectal cancer (CRC) in Extracellular vesicles (EVs), by using a novel multilabel system based on encapsulated iron oxide (IONs) nanoparticles. The IONs were prepared by a microemulsion mehod, and their encapsulation was more efficient using the thin film hydration layer method than by ethanol injection. The performance of the encapsulated particles as detecting labels was compared with that achieved using the conventional gold nanoparticles (AuNPs). Our results indicate that encapsulated IONs increased the sensitivity by means of their nanozyme effect towards the oxidation of hydrogen peroxide. The nanovesicles encapsulating IONs could improve their safety handling and sample preparation, and they could be useful at other sensing fields.
{"title":"Magnetic nanovesicles as multilabel systems in lateral flow immunoassays","authors":"Paula Suárez-Vaquero , Beatriz Rodríguez , Amanda Moyano , Baihui Wang , Alberto Sánchez-Calvo , Esther Serrano-Pertierra , José María Duque , Luis Sánchez , Guillermo García-Santos , Luis García-Flórez , Gemma Gutiérrez , María Matos , María Carmen Blanco-López","doi":"10.1016/j.colcom.2026.100870","DOIUrl":"10.1016/j.colcom.2026.100870","url":null,"abstract":"<div><div>Lateral flow assays (LFA) have been widely used for rapid and low-cost detection of biomolecules in a variety of fields. In this work, we have developed a LFA for potential biomarkers of colorectal cancer (CRC) in Extracellular vesicles (EVs), by using a novel multilabel system based on encapsulated iron oxide (IONs) nanoparticles. The IONs were prepared by a microemulsion mehod, and their encapsulation was more efficient using the thin film hydration layer method than by ethanol injection. The performance of the encapsulated particles as detecting labels was compared with that achieved using the conventional gold nanoparticles (AuNPs). Our results indicate that encapsulated IONs increased the sensitivity by means of their nanozyme effect towards the oxidation of hydrogen peroxide. The nanovesicles encapsulating IONs could improve their safety handling and sample preparation, and they could be useful at other sensing fields.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"71 ","pages":"Article 100870"},"PeriodicalIF":4.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1016/j.colcom.2026.100872
Zixi Yin , Xingchen Liu , Guijie Liang , Song Wang
Photocatalysis hydrogen production is a sustainable method for generating clean energy from solar power, yet a critical challenge lies in developing photocatalysts with both high activity and facile synthesis. Herein, we propose an innovative interfacial crosslinking strategy, for the first time employing the bifunctional crosslinker CHO-PEG-CHO to mediate the construction of C3N5/Fe-MOF heterojunctions. Terminal aldehydes of PEG specifically react with amino groups in Fe-MOF and hydroxyl groups in C3N5 to form a stable superhydrophilic PEG@C3N5/Fe-MOF composite with a remarkable H₂ evolution rate of 4311 μmol·g−1·h−1 (7.9 times higher than pure C3N5). The exceptional performance originates from the combined effect of a S-scheme charge transfer mechanism for efficient charge separation and optimized redox potentials, and a PEG-enhanced C3N5-Fe-MOF interaction, validated by time-resolved photoluminescence (PL) alongside transient absorption spectroscopy (TA). This rational crosslinking strategy and elucidated S-scheme pathway provide a new platform for designing highly efficient and stable photocatalysts for solar-driven hydrogen production and broader photocatalytic applications.
{"title":"PEG crosslinking constructs superhydrophilic S-scheme heterojunction: A novel strategy for highly efficient H2 production over Fe-MOF/C3N5 photocatalyst","authors":"Zixi Yin , Xingchen Liu , Guijie Liang , Song Wang","doi":"10.1016/j.colcom.2026.100872","DOIUrl":"10.1016/j.colcom.2026.100872","url":null,"abstract":"<div><div>Photocatalysis hydrogen production is a sustainable method for generating clean energy from solar power, yet a critical challenge lies in developing photocatalysts with both high activity and facile synthesis. Herein, we propose an innovative interfacial crosslinking strategy, for the first time employing the bifunctional crosslinker CHO-PEG-CHO to mediate the construction of C<sub>3</sub>N<sub>5</sub>/Fe-MOF heterojunctions. Terminal aldehydes of PEG specifically react with amino groups in Fe-MOF and hydroxyl groups in C<sub>3</sub>N<sub>5</sub> to form a stable superhydrophilic PEG@C<sub>3</sub>N<sub>5</sub>/Fe-MOF composite with a remarkable H₂ evolution rate of 4311 μmol·g<sup>−1</sup>·h<sup>−1</sup> (7.9 times higher than pure C<sub>3</sub>N<sub>5</sub>). The exceptional performance originates from the combined effect of a S-scheme charge transfer mechanism for efficient charge separation and optimized redox potentials, and a PEG-enhanced C<sub>3</sub>N<sub>5</sub>-Fe-MOF interaction, validated by time-resolved photoluminescence (PL) alongside transient absorption spectroscopy (TA). This rational crosslinking strategy and elucidated S-scheme pathway provide a new platform for designing highly efficient and stable photocatalysts for solar-driven hydrogen production and broader photocatalytic applications.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"71 ","pages":"Article 100872"},"PeriodicalIF":4.7,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.colcom.2025.100868
Candelaria Ines Camara , Caterina Ricci , Laura Bertocchi , Rosaria Bassi , Annalisa Bianchera , Ruggero Bettini , Elena Del Favero
The delivery of poorly soluble drugs poses significant challenges in pharmacotherapy, particularly for corticosteroids. This study investigates the development of hyaluronic acid-based nanoparticles to enhance the solubility and bioavailability of dexamethasone. Hyaluronic acid-dexamethasone formulations, (HAm 15–30 kDa and HAl 750–1000 kDa), were produced as stable powders to be resuspended. We characterized the nanoparticles formed after resuspension by laser-light and X-ray scattering. Nanoparticles showed nanometric size, good stability, a core-shell arrangement, and muco-inert properties. We evaluated the interaction of nanoparticles with lung surfactant models, by nebulization of formulations on DPPC Langmuir monolayers to mimic their effects on alveolar interfaces when administered via nebulization. They showed good biocompatibility and enhanced anti-inflammatory response, as assessed by pro-inflammatory cytokine TNF-α release in LPS-stimulated macrophages. The favorable structural and biopharmaceutical characteristics of HA-based formulations can be exploited to improve the delivery of poorly soluble drugs to the lungs by inhalation.
{"title":"Hyaluronic acid-based nanoparticles for pulmonary delivery of poorly soluble drugs","authors":"Candelaria Ines Camara , Caterina Ricci , Laura Bertocchi , Rosaria Bassi , Annalisa Bianchera , Ruggero Bettini , Elena Del Favero","doi":"10.1016/j.colcom.2025.100868","DOIUrl":"10.1016/j.colcom.2025.100868","url":null,"abstract":"<div><div>The delivery of poorly soluble drugs poses significant challenges in pharmacotherapy, particularly for corticosteroids. This study investigates the development of hyaluronic acid-based nanoparticles to enhance the solubility and bioavailability of dexamethasone. Hyaluronic acid-dexamethasone formulations, (HAm 15–30 kDa and HAl 750–1000 kDa), were produced as stable powders to be resuspended. We characterized the nanoparticles formed after resuspension by laser-light and X-ray scattering. Nanoparticles showed nanometric size, good stability, a core-shell arrangement, and muco-inert properties. We evaluated the interaction of nanoparticles with lung surfactant models, by nebulization of formulations on DPPC Langmuir monolayers to mimic their effects on alveolar interfaces when administered via nebulization. They showed good biocompatibility and enhanced anti-inflammatory response, as assessed by pro-inflammatory cytokine TNF-α release in LPS-stimulated macrophages. The favorable structural and biopharmaceutical characteristics of HA-based formulations can be exploited to improve the delivery of poorly soluble drugs to the lungs by inhalation.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"70 ","pages":"Article 100868"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.colcom.2026.100871
Alexandre Epalle, Stéphane Valette
In wetting theory, it has been defined that contact angle hysteresis and, more generally, dynamic behavior originate from the imperfect nature of the surface, such as chemical and topographical asperities. In the case of chemical heterogeneities, the clustering effect of polar and non-polar groups is assumed to be at the origin of droplet anchoring behavior. Then, on a microscopic scale, the organization of these groups should have an impact on wetting dynamics. As a hypothesis, for an identical surface ratio of two distinct chemistries with the same asperity size, a surface with a chaotic chemical distribution will generate more anchoring than an organized surface. To verify this approach, a numerical model was applied to wetting on textured chemical surfaces. Numerical wetting simulations were developed to simulate wetting in a manner similar to a sessile drop experiment followed by a tilt test. In addition, thanks to the numerical method, it was possible to precisely define different chemical textures, ranging from a totally chaotic texture to an organized one. Dynamic anchoring behaviors were then characterized, for each surface, by the evolution of the triple line velocity during droplet sliding. As a result, the simulations validate the initial hypothesis with the observation of stronger dynamic anchoring during tilting for randomly textured surfaces. This behavior is directly linked to the clustering effect, which creates favorable anchoring sites. It has been shown that this clustering effect also leads to local stick–slip phenomena of the triple line around the droplet.
{"title":"Impact of chaotic or organized chemical texturing on wetting dynamics using numerical simulations","authors":"Alexandre Epalle, Stéphane Valette","doi":"10.1016/j.colcom.2026.100871","DOIUrl":"10.1016/j.colcom.2026.100871","url":null,"abstract":"<div><div>In wetting theory, it has been defined that contact angle hysteresis and, more generally, dynamic behavior originate from the imperfect nature of the surface, such as chemical and topographical asperities. In the case of chemical heterogeneities, the clustering effect of polar and non-polar groups is assumed to be at the origin of droplet anchoring behavior. Then, on a microscopic scale, the organization of these groups should have an impact on wetting dynamics. As a hypothesis, for an identical surface ratio of two distinct chemistries with the same asperity size, a surface with a chaotic chemical distribution will generate more anchoring than an organized surface. To verify this approach, a numerical model was applied to wetting on textured chemical surfaces. Numerical wetting simulations were developed to simulate wetting in a manner similar to a sessile drop experiment followed by a tilt test. In addition, thanks to the numerical method, it was possible to precisely define different chemical textures, ranging from a totally chaotic texture to an organized one. Dynamic anchoring behaviors were then characterized, for each surface, by the evolution of the triple line velocity during droplet sliding. As a result, the simulations validate the initial hypothesis with the observation of stronger dynamic anchoring during tilting for randomly textured surfaces. This behavior is directly linked to the clustering effect, which creates favorable anchoring sites. It has been shown that this clustering effect also leads to local stick–slip phenomena of the triple line around the droplet.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"70 ","pages":"Article 100871"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.colcom.2025.100866
Dongmei Mei , Xuechen Zhu , Wen Su , Li Mei , Baodong Zhao , Jiang Chen
Porous scaffolds based on calcium phosphate have extensive applications in the field of bone repair due to their excellent structural biomimicry, biocompatibility and bone conductivity. In this study, type I collagen and alginate matrix, lipoic acid and its sodium salts were successively applied for the modification of coral-derived porous scaffolds. The systematic characterization results showed that the modification operation retained its interconnected pore structure and significantly improves the compression and three-point bending mechanical properties. The results indicated that the introduction of collagen significantly improved the cell adhesion and proliferation activity of the porous scaffold, and the lipoic acid groups further enhanced the antibacterial performance of the composite scaffold. The ectopic osteogenesis in mouse muscle pockets experimental results indicated that the modified porous scaffold has significantly enhanced cell recruitment ability and early osteogenic differentiation, which make it a promising biomaterial for oral and maxillofacial bone regeneration.
{"title":"Collagen/alginate/lipoic acid modified coral-derived porous scaffold promotes osteogenesis","authors":"Dongmei Mei , Xuechen Zhu , Wen Su , Li Mei , Baodong Zhao , Jiang Chen","doi":"10.1016/j.colcom.2025.100866","DOIUrl":"10.1016/j.colcom.2025.100866","url":null,"abstract":"<div><div>Porous scaffolds based on calcium phosphate have extensive applications in the field of bone repair due to their excellent structural biomimicry, biocompatibility and bone conductivity. In this study, type I collagen and alginate matrix, lipoic acid and its sodium salts were successively applied for the modification of coral-derived porous scaffolds. The systematic characterization results showed that the modification operation retained its interconnected pore structure and significantly improves the compression and three-point bending mechanical properties. The results indicated that the introduction of collagen significantly improved the cell adhesion and proliferation activity of the porous scaffold, and the lipoic acid groups further enhanced the antibacterial performance of the composite scaffold. The ectopic osteogenesis in mouse muscle pockets experimental results indicated that the modified porous scaffold has significantly enhanced cell recruitment ability and early osteogenic differentiation, which make it a promising biomaterial for oral and maxillofacial bone regeneration.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"70 ","pages":"Article 100866"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study investigated how subtle variations in the number of substituent groups in hydroxypropyl methylcellulose (HPMC) affect its interaction with chitosan surfaces. We used a model system with ultra-thin chitosan films on QCM-D sensors to probe the adsorption of various HPMC grades. The HPMCs had similar molecular weights but differed in their degree of substitution, which was shown to affect their solubility. Hansen solubility parameters and dynamic light scattering (DLS) data revealed that lower solubility and higher aggregation led to stronger adsorption. QCM-D measurements confirmed irreversible adsorption for all HPMC variants, with the least soluble grade exhibiting the highest adsorption. These findings demonstrate that lower solubility enhances HPMC adsorption onto chitosan, providing valuable insights for optimizing polymer interactions in applications such as oral film formulations.
{"title":"The influence of substituents of cellulose ethers on their interaction with chitosan surfaces","authors":"Vishnu Arumughan , Karin Korelc , Ingunn Tho , Anette Larsson","doi":"10.1016/j.colcom.2025.100867","DOIUrl":"10.1016/j.colcom.2025.100867","url":null,"abstract":"<div><div>This study investigated how subtle variations in the number of substituent groups in hydroxypropyl methylcellulose (HPMC) affect its interaction with chitosan surfaces. We used a model system with ultra-thin chitosan films on QCM-D sensors to probe the adsorption of various HPMC grades. The HPMCs had similar molecular weights but differed in their degree of substitution, which was shown to affect their solubility. Hansen solubility parameters and dynamic light scattering (DLS) data revealed that lower solubility and higher aggregation led to stronger adsorption. QCM-D measurements confirmed irreversible adsorption for all HPMC variants, with the least soluble grade exhibiting the highest adsorption. These findings demonstrate that lower solubility enhances HPMC adsorption onto chitosan, providing valuable insights for optimizing polymer interactions in applications such as oral film formulations.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"70 ","pages":"Article 100867"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.colcom.2025.100869
Song-Hao Nguyen Ho , Hoan Ngoc Doan , Quoc Hien Nguyen , Thi-Hiep Nguyen , Long Binh Vong
Chronic wounds, characterised by severe inflammation, excessive oxidation, and bacterial infection, remain a challenge in tissue healing treatment. Biopolymer-based hydrogels offer a promising alternative, promoting dermal and epidermal regeneration while protecting against microbial infections. Chitosan oligosaccharide (COS), a natural biopolymer with wound-healing potential, and chicken egg white–derived ovalbumin, known for enhancing cell growth, were combined to develop a novel hydrogel system. In this study, a hydrogel was formulated from sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC), incorporating COS and egg protein nanoparticles (EPN) prepared via cold gelation, with CaCl₂ serving as the crosslinker. COS was obtained by degrading chitosan in diluted lactic acid with hydrogen peroxide. EPN size and mechanical strength of fabricated hydrogels were evaluated using dynamic light scattering and tensile testing, respectively. The cytotoxicity and anti-inflammatory activity were assessed in vitro. The resulting hydrogel was designed to exhibit favourable tensile strength, swelling behavior, low cytotoxicity, and high antioxidant activity, as well as anti-inflammatory properties. Using the excisional wound-healing model in mice, treatment of the hydrogel with EPN and COS exhibited significantly higher therapeutic efficacy in promoting tissue regeneration and the healing process.
{"title":"Preparation of hydrogel dressing containing chitosan oligosaccharide and egg white nanoparticles for enhanced wound healing application","authors":"Song-Hao Nguyen Ho , Hoan Ngoc Doan , Quoc Hien Nguyen , Thi-Hiep Nguyen , Long Binh Vong","doi":"10.1016/j.colcom.2025.100869","DOIUrl":"10.1016/j.colcom.2025.100869","url":null,"abstract":"<div><div>Chronic wounds, characterised by severe inflammation, excessive oxidation, and bacterial infection, remain a challenge in tissue healing treatment. Biopolymer-based hydrogels offer a promising alternative, promoting dermal and epidermal regeneration while protecting against microbial infections. Chitosan oligosaccharide (COS), a natural biopolymer with wound-healing potential, and chicken egg white–derived ovalbumin, known for enhancing cell growth, were combined to develop a novel hydrogel system. In this study, a hydrogel was formulated from sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC), incorporating COS and egg protein nanoparticles (EPN) prepared <em>via</em> cold gelation, with CaCl₂ serving as the crosslinker. COS was obtained by degrading chitosan in diluted lactic acid with hydrogen peroxide. EPN size and mechanical strength of fabricated hydrogels were evaluated using dynamic light scattering and tensile testing, respectively. The cytotoxicity and anti-inflammatory activity were assessed <em>in vitro</em>. The resulting hydrogel was designed to exhibit favourable tensile strength, swelling behavior, low cytotoxicity, and high antioxidant activity, as well as anti-inflammatory properties. Using the excisional wound-healing model in mice, treatment of the hydrogel with EPN and COS exhibited significantly higher therapeutic efficacy in promoting tissue regeneration and the healing process.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"70 ","pages":"Article 100869"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.colcom.2025.100865
Haili Wang , Jia Wang , Li Ma , Yuan Wei , Shisheng Cui , Tingting Miao , Mei Chai , Zhenglai Qiu , Xiaolong Zhu
Pathogenic oral biofilms pose a major global health challenge due to their resilience and the limitations of conventional treatments. Silver nanoparticles (AgNPs) are a promising alternative, yet their efficacy is limited by poor colloidal stability and restricted matrix penetration. This review explores the rational design of innovative silver nanoplatforms to overcome these barriers. We focus on strategic interface engineering that enables stimuli-responsive activation, enhanced targeting, and improved retention within the complex oral biofilm microenvironment. The mechanisms and performance of polymer-functionalized, encapsulated, template-supported, and hybrid AgNP systems are critically examined. Furthermore, we analyze their clinical potential in managing oral infections and discuss the key translation challenges and future directions. By synthesizing current knowledge, this review aims to provide valuable insights that will guide the development of advanced nanotherapeutic strategies for effective oral biofilm management.
{"title":"Innovative silver nanoplatforms: Overcoming challenges in oral biofilm treatment","authors":"Haili Wang , Jia Wang , Li Ma , Yuan Wei , Shisheng Cui , Tingting Miao , Mei Chai , Zhenglai Qiu , Xiaolong Zhu","doi":"10.1016/j.colcom.2025.100865","DOIUrl":"10.1016/j.colcom.2025.100865","url":null,"abstract":"<div><div>Pathogenic oral biofilms pose a major global health challenge due to their resilience and the limitations of conventional treatments. Silver nanoparticles (AgNPs) are a promising alternative, yet their efficacy is limited by poor colloidal stability and restricted matrix penetration. This review explores the rational design of innovative silver nanoplatforms to overcome these barriers. We focus on strategic interface engineering that enables stimuli-responsive activation, enhanced targeting, and improved retention within the complex oral biofilm microenvironment. The mechanisms and performance of polymer-functionalized, encapsulated, template-supported, and hybrid AgNP systems are critically examined. Furthermore, we analyze their clinical potential in managing oral infections and discuss the key translation challenges and future directions. By synthesizing current knowledge, this review aims to provide valuable insights that will guide the development of advanced nanotherapeutic strategies for effective oral biofilm management.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"70 ","pages":"Article 100865"},"PeriodicalIF":4.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1016/j.colcom.2025.100864
Siuman Leung , Xiaohong Li , Xiaoqiong Huang , Ruogu Xu , Hio Kuan Wu , Jiali Deng , Feilong Deng , Shuang-Zhuang Guo , Yun Liu
This study developed a three-dimensional (3D)-printed dual-controlled release scaffold for localized, sustained parathyroid hormone 1–34 (PTH 1–34) delivery to overcome systemic limitations (inadequate spatiotemporal control, poor anatomical matching) and enhance early bone regeneration in osteoporotic defects. PTH(1–34)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres (68.2 % efficiency) were incorporated into chitosan (CS) /short rod-shaped nano-hydroxyapatite (nHA) hydrogel ink and 3D-printed (300 μm nozzle). In vitro, scaffolds exhibited sustained biphasic release (19.4 ± 2.1 % initial burst within 24 h and 71.8 ± 1.7 % cumulative release over 30 days), significantly promoting MC3T3-E1 proliferation, alkaline phosphatase (ALP) activity (3.08-fold vs control, day 14; p < 0.01), and runt-related transcription factor 2 (Runx2) expression (8.13-fold; p < 0.001). In vivo (Ovariectomy rats, 5-mm calvarial defects; n = 5/group), Micro-computed tomography (micro-CT) at 4 weeks showed 2.22-fold higher trabecular bone volume fraction (BV/TV) (p < 0.001) with 73 % greater trabecular thickness (p < 0.001), confirmed histologically by accelerated mineralization/osteoblast activation. The PTH(1–34)@PLGA/CS-nHA scaffold integrates spatiotemporal drug delivery and biomimetic architecture, offering a promising strategy for early-phase bone regeneration in osteoporosis.
Pub Date : 2025-11-20DOI: 10.1016/j.colcom.2025.100863
Shairy Priya , Rishabha Malviya , Saurabh Srivastava , Tan Ching Siang , Abdullah A. Aseeri
Microbial biofouling threatens healthcare, water treatment and food systems by promoting resilient biofilms, reducing device lifetime and increasing infection risk. Bioinspired nano- and micro-structured surfaces (NMSS) offer non-leaching, physics-driven antifouling and mechano-bactericidal strategies that aim to reduce reliance on toxic biocides. This review evaluates advances in bioinspired surface engineering, emphasizing the comparative performance, material trade-offs, and long-term stability of antifouling and antimicrobial strategies. NMSS reduces the real contact area, increases local shear, and, for dense high-aspect-ratio features, imposes membrane deformation that can cause lysis; bactericidal and antifouling efficacy depends on pillar height, tip radius, spacing, substrate stiffness, and wettability. Multiscale models link nanoscale membrane stresses to mesoscale transport and critical shear thresholds, allowing geometry selection tailored to flow regimes and microbial types. Hybrid strategies that combine topography with benign chemistries (zwitterions, photocatalysts) and stimuli-responsive actuation enhance robustness under protein conditioning and mixed-species biofilms while reducing ecological load. In conclusion, the combination of multiscale physics, machine-learning optimisation, and sensor-integrated maintenance, along with bioinspired NMSS, can deliver scalable, lower-impact antifouling solutions.
{"title":"Bioinspired nanostructured surfaces for antimicrobial and antifouling applications","authors":"Shairy Priya , Rishabha Malviya , Saurabh Srivastava , Tan Ching Siang , Abdullah A. Aseeri","doi":"10.1016/j.colcom.2025.100863","DOIUrl":"10.1016/j.colcom.2025.100863","url":null,"abstract":"<div><div>Microbial biofouling threatens healthcare, water treatment and food systems by promoting resilient biofilms, reducing device lifetime and increasing infection risk. Bioinspired nano- and micro-structured surfaces (NMSS) offer non-leaching, physics-driven antifouling and mechano-bactericidal strategies that aim to reduce reliance on toxic biocides. This review evaluates advances in bioinspired surface engineering, emphasizing the comparative performance, material trade-offs, and long-term stability of antifouling and antimicrobial strategies. NMSS reduces the real contact area, increases local shear, and, for dense high-aspect-ratio features, imposes membrane deformation that can cause lysis; bactericidal and antifouling efficacy depends on pillar height, tip radius, spacing, substrate stiffness, and wettability. Multiscale models link nanoscale membrane stresses to mesoscale transport and critical shear thresholds, allowing geometry selection tailored to flow regimes and microbial types. Hybrid strategies that combine topography with benign chemistries (zwitterions, photocatalysts) and stimuli-responsive actuation enhance robustness under protein conditioning and mixed-species biofilms while reducing ecological load. In conclusion, the combination of multiscale physics, machine-learning optimisation, and sensor-integrated maintenance, along with bioinspired NMSS, can deliver scalable, lower-impact antifouling solutions.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"70 ","pages":"Article 100863"},"PeriodicalIF":4.7,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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