Cell mechanics in early vertebrate development: Yap mechanotransduction controls notochord formation and neural tube patterning

Zheng Guo, Jing Du
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Abstract

A recent study published in Science Advances1 showed the influence of Yap on notochord formation and NT (neural tube) patterning in vertebrate embryonic development, and conducted an in-depth study from the perspective of biomechanical signal mechanotransduction. In addition, this study also explored the possible complex interaction between mechanical signals and gene expression. Together, this study provides new insights into the development mechanism of early vertebrate embryos.

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早期脊椎动物发育中的细胞力学:Yap机械转导控制脊索形成和神经管模式
最近发表在Science advances杂志上的一项研究显示了Yap对脊椎动物胚胎发育中脊索形成和NT(神经管)模式的影响,并从生物力学信号机械转导的角度进行了深入研究。此外,本研究还探讨了机械信号与基因表达之间可能存在的复杂相互作用。总之,这项研究为早期脊椎动物胚胎的发育机制提供了新的见解。
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