Modern Macrolactonization Techniques

IF 2.2 4区 化学 Q2 CHEMISTRY, ORGANIC Synthesis-Stuttgart Pub Date : 2023-09-26 DOI:10.1055/a-2181-9800
Max Van Hoof, Guillaume Force, David Leboeuf
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Abstract

Abstract The study of macrolactonization processes has been a steady endeavor for synthetic chemists to access macrocycles that are fundamental in the development of numerous high-added-value compounds, notably drugs and fragrances. This field of research is essential as macrolactonizations usually take place at the end of manifold syntheses and chemists need reliable, efficient, and versatile tools to avoid unpredictable results that would lead them to completely redesign their synthetic plan. Here, we highlight the recent methods reported to achieve macrolactonizations towards the formation of both macrolactones and macrodiolides, which feature either Lewis acids, transition metals or organic molecules as activating agents. 1 Introduction 2 Stoichiometric Carboxylic Acid Activation 3 Lewis Acid Catalyzed Reaction 4 C–H Activation 5 Ring-Expansion Strategy 6 Chemoenzymatic Synthesis 7 Other Macrolactonization Variants 8 Conclusion and Outlook

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现代大内酯化技术
大内酯化过程的研究一直是合成化学家获得大环的稳定努力,大环是开发许多高附加值化合物,特别是药物和香料的基础。这一领域的研究是必不可少的,因为大内酯化通常发生在多种合成的最后,化学家需要可靠、高效和通用的工具来避免不可预测的结果,从而导致他们完全重新设计他们的合成计划。在这里,我们重点介绍了最近报道的实现大内酯化的方法,以形成大内酯和大内酯,其特征要么是路易斯酸,过渡金属或有机分子作为活化剂。1 .概述2 .化学计量羧酸活化3 . Lewis酸催化反应4 . C-H活化5 .扩环策略6 .化学酶合成7 .其他大内酯化变体8 .结论与展望
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来源期刊
Synthesis-Stuttgart
Synthesis-Stuttgart 化学-有机化学
CiteScore
4.50
自引率
7.70%
发文量
435
审稿时长
1 months
期刊介绍: SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.
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