Genetic polymorphisms associated with sepsis incidence, severity, and outcomes among neonates: A mini-review

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-01-01 DOI:10.4103/japtr.japtr_332_23
Darnifayanti Darnifayanti, Muslim Akmal, Syahrun Nur, Sulaiman Yusuf
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Abstract

Genetic variation remains a topic of great interest due to its potential as a risk factor for various diseases. Interactions between genes contribute to diverse phenotypes in response to factors such as infection. The impact of genetic background on susceptibility and clinical outcomes, particularly in neonatal sepsis, has gained recognition. The variability in sepsis susceptibility and outcomes can be attributed to the genetic diversity in coding regions and regulatory elements of genes related to innate immune response. Recent advances in genomics and technology have shed light on genetic polymorphisms among humans, often represented by single-nucleotide polymorphisms (SNPs). These SNPs encode proteins crucial for recognizing and responding to pathogenic bacteria, including Toll-like receptor 4, CD14, tumor necrosis factor-alpha, as well as interleukin-1-10. This literature review specifically discusses the involvement of genetic polymorphism during the pathogenesis stage of sepsis, with an emphasis on previous research findings in neonatal sepsis cases, aiming to discuss the implications of polymorphism in sepsis susceptibility and outcomes.
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新生儿中与脓毒症发生率、严重程度和结局相关的遗传多态性:一项小型综述
遗传变异仍然是一个非常感兴趣的话题,因为它可能是各种疾病的危险因素。基因之间的相互作用有助于对感染等因素的反应产生不同的表型。遗传背景对易感性和临床结果的影响,特别是在新生儿败血症中,已经得到了认可。脓毒症易感性和结果的可变性可归因于与先天免疫反应相关的基因编码区和调控元件的遗传多样性。基因组学和技术的最新进展揭示了人类遗传多态性,通常以单核苷酸多态性(SNPs)为代表。这些snp编码的蛋白质对识别和响应致病菌至关重要,包括toll样受体4、CD14、肿瘤坏死因子- α和白细胞介素-1-10。本文献综述专门讨论了遗传多态性在脓毒症发病阶段的参与,重点介绍了以往在新生儿脓毒症病例中的研究成果,旨在探讨多态性在脓毒症易感性和结局中的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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